about
The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with BakStapled BH3 peptides against MCL-1: mechanism and design using atomistic simulationsPan-Bcl-2 inhibitor obatoclax delays cell cycle progression and blocks migration of colorectal cancer cellsOblimersen in combination with temozolomide and albumin-bound paclitaxel in patients with advanced melanoma: a phase I trial.Directed elimination of senescent cells by inhibition of BCL-W and BCL-XLThe downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition.ABT-737 induces Bim expression via JNK signaling pathway and its effect on the radiation sensitivity of HeLa cellsProspects on strategies for therapeutically targeting oncogenic regulatory factors by small-molecule agents2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine.Small molecule inhibitors of bcl-2 family proteins for pancreatic cancer therapyPleomorphic liposarcoma: clinical observations and molecular variables.BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells.Differential control of growth, apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs, Rhazya stricta and Zingiber officinale and their combinationProgress in Small Molecule Therapeutics for the Treatment of Retinoblastoma.Celecoxib and Bcl-2: emerging possibilities for anticancer drug design.CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies.Broad targeting of resistance to apoptosis in cancer.Targeted genomic sequencing of pediatric Burkitt lymphoma identifies recurrent alterations in antiapoptotic and chromatin-remodeling genes.Salubrinal-Mediated Upregulation of eIF2α Phosphorylation Increases Doxorubicin Sensitivity in MCF-7/ADR Cells.Altering cell death pathways as an approach to cure HIV infection.Small molecules as pro-apoptotic anticancer agents.HIV-1 latency in monocytes/macrophagesMethionine adenosyltransferase α2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells.Biological relevance of Hsp90-binding immunophilins in cancer development and treatment.New dimension in therapeutic targeting of BCL-2 family proteins.S-Adenosylmethionine-mediated apoptosis is potentiated by autophagy inhibition induced by chloroquine in human breast cancer cells.Galectin-3 promotes caspase-independent cell death of HIV-1-infected macrophages.Therapeutic Options for Retinoblastoma.Curcumin induces cell death of the main molecular myeloma subtypes, particularly the poor prognosis subgroups.The effect of cilengitide in combination with irradiation and chemotherapy in head and neck squamous cell carcinoma cell lines.Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling.Effect of miR-451 on the biological behavior of the esophageal carcinoma cell line EC9706.Perturbing pro-survival proteins using quinoxaline derivatives: a structure-activity relationship study.Inhibitors of the Antiapoptotic Myeloid Cell Leukemia-1 (Mcl-1) May Provide Effective Treatment for Cancer.Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure.The role of apoptosis in the pathology of pancreatic cancerIn vitro and in vivo anti-leukemic effects of cladoloside C2 are mediated by activation of Fas/ceramide synthase 6/p38 kinase/c-Jun NH2-terminal kinase/caspase-8.Regulation of HA14-1 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells.Holotoxin A₁ Induces Apoptosis by Activating Acid Sphingomyelinase and Neutral Sphingomyelinase in K562 and Human Primary Leukemia Cells.Bufalin and 5-fluorouracil synergistically induce apoptosis in colorectal cancer cells.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Emerging Bcl-2 inhibitors for the treatment of cancer.
@ast
Emerging Bcl-2 inhibitors for the treatment of cancer.
@en
type
label
Emerging Bcl-2 inhibitors for the treatment of cancer.
@ast
Emerging Bcl-2 inhibitors for the treatment of cancer.
@en
prefLabel
Emerging Bcl-2 inhibitors for the treatment of cancer.
@ast
Emerging Bcl-2 inhibitors for the treatment of cancer.
@en
P2093
P2860
P1476
Emerging Bcl-2 inhibitors for the treatment of cancer.
@en
P2093
Asfar S Azmi
Fazlul H Sarkar
Philip A Philip
Ramzi M Mohammad
Zhiwei Wang
P2860
P356
10.1517/14728214.2010.515210
P407
P577
2010-09-03T00:00:00Z