A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies.
about
Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models.Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility.Effects of [Nphe1, Arg14, Lys15] N/OFQ-NH2 (UFP-101), a potent NOP receptor antagonist, on molecular, cellular and behavioural alterations associated with chronic mild stress.Social defeat disrupts reward learning and potentiates striatal nociceptin/orphanin FQ mRNA in rats.Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale.Preclinical findings predicting efficacy and side-effect profile of LY2940094, an antagonist of nociceptin receptors.Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction.In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations.Beta-arrestin 2 rather than G protein efficacy determines the anxiolytic-versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligands.In vitro pharmacological characterization of a novel unbiased NOP receptor-selective nonpeptide agonist AT-403.Occupancy of Nociceptin/Orphanin FQ Peptide Receptors by the Antagonist LY2940094 in Rats and Healthy Human Subjects.Advances in Pharmacotherapy Development: Human Clinical Studies.Panicolytic-like effects caused by substantia nigra pars reticulata pretreatment with low doses of endomorphin-1 and high doses of CTOP or the NOP receptors antagonist JTC-801 in male Rattus norvegicus.Proof-of-Concept Study to Assess the Nociceptin Receptor Antagonist LY2940094 as a New Treatment for Alcohol Dependence.A systematic review of the role of the nociceptin receptor system in stress, cognition, and reward: relevance to schizophrenia.Real-Time Functional Magnetic Resonance Imaging Amygdala Neurofeedback Changes Positive Information Processing in Major Depressive Disorder.Antidepressant activity of nociceptin/orphanin FQ receptor antagonists in the mouse learned helplessness.Nociceptin Receptor as a Target to Treat Alcohol Use Disorder: Challenges in Advancing Medications Development.Nociceptin/orphanin FQ receptor ligands and translational challenges: focus on cebranopadol as an innovative analgesic
P2860
Q36744366-C43C2BB9-049F-4316-BDB3-7F16098A15E8Q36835278-213EB1FD-77C1-4CAF-ACDB-78DEBD7C5A08Q37030102-8A32B55B-2678-440A-8CEF-CB1DDD1AAAD4Q37211503-64EA0B86-EC24-4A3B-BD2A-C37274AA3D94Q38833155-5106702C-DDDA-4EB5-8859-BD466619A23FQ38915717-9DDE84A8-B140-4195-8D40-C201A7341F4EQ38969500-E9DEED15-28C4-49E4-BF51-575082CFAC1FQ39015847-F8F6AEDF-29C1-41DB-A62C-380828BF77B2Q39296074-5111BB28-6973-4C97-847F-3CB0D3A4FD78Q41380155-93B501DF-2F81-4B8A-A943-6F3A1984F64BQ41493064-39700FE1-82CF-4E22-9DFD-75E346732E77Q45998228-4153B444-B2E2-4E98-8546-C9E22A33343FQ46526074-F9CC64AF-9F4B-45A0-AB90-D9E0162C67B0Q47182010-0BB25D4A-24E2-4BA2-9227-B70DF41F926CQ47300004-620FC29C-C2B4-47C5-8132-DCE4865FFB35Q47409005-2F65A070-DECF-43EC-A7D6-B023315095CFQ47549684-BB5E5BC7-44E7-46D0-B167-438F8C616010Q47896005-BFB091FE-0280-4E56-AACF-B5B3CD86292EQ48056790-F29B2DB2-4D69-4352-8890-A7EFF181DE6AQ51438275-38ED2929-4CA1-46C0-A359-9606E6B8A6D5Q58545262-530E4A7A-8A7B-4AC8-90A1-E5D554497A87
P2860
A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies.
description
2015 nî lūn-bûn
@nan
2015 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
A Selective Nociceptin Recepto ...... clinical and Clinical Studies.
@ast
A Selective Nociceptin Recepto ...... clinical and Clinical Studies.
@en
A Selective Nociceptin Recepto ...... clinical and Clinical Studies.
@nl
type
label
A Selective Nociceptin Recepto ...... clinical and Clinical Studies.
@ast
A Selective Nociceptin Recepto ...... clinical and Clinical Studies.
@en
A Selective Nociceptin Recepto ...... clinical and Clinical Studies.
@nl
prefLabel
A Selective Nociceptin Recepto ...... clinical and Clinical Studies.
@ast
A Selective Nociceptin Recepto ...... clinical and Clinical Studies.
@en
A Selective Nociceptin Recepto ...... clinical and Clinical Studies.
@nl
P2093
P2860
P356
P1476
A Selective Nociceptin Recepto ...... clinical and Clinical Studies.
@en
P2093
Andrew McCarthy
Gerard R Dawson
Jeffrey M Witkin
Judith Krikke-Workel
Keith Wafford
Kimberley Jackson
Michael Statnick
Richard Mohs
Rishi Kakar
P2860
P2888
P304
P356
10.1038/NPP.2015.348
P407
P577
2015-11-20T00:00:00Z
P6179
1033447521