The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex.
about
Biochemical conservation and evolution of germacrene A oxidase in asteraceaeThe sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cellsComparative effects of the herbal constituent parthenolide (Feverfew) on lipopolysaccharide-induced inflammatory gene expression in murine spleen and liver.Morphine exacerbates HIV-1 Tat-induced cytokine production in astrocytes through convergent effects on [Ca(2+)](i), NF-kappaB trafficking and transcriptionTWEAK activates the non-canonical NFkappaB pathway in murine renal tubular cells: modulation of CCL21Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assayNF-kappaB activation during Rickettsia rickettsii infection of endothelial cells involves the activation of catalytic IkappaB kinases IKKalpha and IKKbeta and phosphorylation-proteolysis of the inhibitor protein IkappaBalphaIdentification of new Rel/NFkappaB regulatory networks by focused genome location analysis.Independent component analysis: mining microarray data for fundamental human gene expression modulesIdentification of small molecules enhancing autophagic function from drug network analysis.Latent membrane protein 1 regulates STAT1 through NF-kappaB-dependent interferon secretion in Epstein-Barr virus-immortalized B cells.Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasomeCD1d ligation on human monocytes directly signals rapid NF-kappaB activation and production of bioactive IL-12.Discovery of drug mode of action and drug repositioning from transcriptional responses.Inhibition of choriodecidual cytokine production and inflammatory gene expression by selective I-kappaB kinase (IKK) inhibitors.TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype.The use of small molecule probes to study spatially separated stimulus-induced signaling pathways.The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells.Involvement of Akt/NF-κB pathway in antitumor effects of parthenolide on glioblastoma cells in vitro and in vivo.A polymeric nanomedicine diminishes inflammatory events in renal tubular cellsNitroglycerin alters matrix remodeling proteins in THP-1 human macrophages and plasma metalloproteinase activity in rats.Contribution of a nuclear factor-kappaB binding site to human angiotensinogen promoter activity in renal proximal tubular cellsRadiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound.Nanodelivery of Parthenolide Using Functionalized Nanographene Enhances its Anticancer Activity.Activation of common antiviral pathways can potentiate inflammatory responses to septic shock.Anti-inflammatory and antiosteoclastogenic activities of parthenolide on human periodontal ligament cells in vitro.Enhancement of 1 alpha,25-dihydroxyvitamin D(3)-induced differentiation of human leukaemia HL-60 cells into monocytes by parthenolide via inhibition of NF-kappa B activityDistinct phenotypes of human prostate cancer cells associate with different adaptation to hypoxia and pro-inflammatory gene expression.Parthenolide induces apoptosis in colitis-associated colon cancer, inhibiting NF-κB signaling.Nuclear factor-kappa B inhibitors as potential novel anti-inflammatory agents for the treatment of immune glomerulonephritisNF-kappaB pathway inhibitors preferentially inhibit breast cancer stem-like cellsChemosensitization in non-small cell lung cancer cells by IKK inhibitor occurs via NF-kappaB and mitochondrial cytochrome c cascade.Can we predict the effects of NF-kappaB inhibition in sepsis? Studies with parthenolide and ethyl pyruvate.Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genesNatural Germacrane Sesquiterpenes Inhibit Osteoclast Formation, Bone Resorption, RANKL-Induced NF-κB Activation, and IκBα Degradation.Potentiation of the anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the kinase inhibitor Staurosporine or its clinically relevant analogue UCN-01The death ligand TRAIL in diabetic nephropathy.The cytokine TWEAK modulates renal tubulointerstitial inflammation.The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparum Sexual Stage Transmission.
P2860
Q24604050-E49C5814-8D87-4ECA-8C48-172C991714B9Q24670343-8044D709-841E-419E-AA74-D23D1E10941EQ24812969-3037650B-90A5-4944-B898-502FCF232570Q28474433-0C6F32CC-C043-4212-BC2D-08183266CB6EQ28749137-B9549B1E-A59C-4470-9D79-D67D51EF76FFQ33256133-09AD74F4-23FE-438A-815D-DC263D1E514FQ33557568-257F73A9-4795-47F7-844F-3C1CC1A75ECFQ33602063-B956C6AC-66DD-47C5-AD53-341AC10EA5FAQ33629605-9071C6DF-9FEB-4AB0-8FBB-2A6ECA822E8DQ33712703-0B60835E-7336-46AB-9354-2B6F9E1A777BQ33724152-A00D806A-38A2-45C2-8D53-9A2393C34EE5Q33744674-6B00B4D4-8AE5-4AD1-883B-F338FD8DA6DAQ33920135-2A045795-327F-4D0D-A1FF-8B1FE78DCC29Q34093341-41AA3199-F941-476B-A080-AEAFB76E76FDQ34116837-531F6BC7-6301-4199-B089-46CA725B277DQ34130168-144FDBC8-DF64-4FB6-9BA8-F11DB8170398Q34149143-8F2BC3DC-6EBC-4E4C-8E3E-5D0B0943B75DQ34176804-F4BBF53A-E491-477A-BC7A-931FE9993781Q34435015-97E7C533-763E-4E3B-9A81-CB4A7416F58BQ34542058-478D7807-4F27-4959-9970-A8468020A39DQ34574503-75FE3B03-CAD2-4D7E-BA40-3AA4DE6124CCQ34635281-1B0A3822-68A8-4746-9574-592C9EC6F95FQ34646655-2BE9F565-D0C0-46FC-98B7-550E0F0B241AQ34822470-A898C7E0-6B4F-4032-A406-30F38B7B8A77Q34885791-B9F7F904-4CAA-4855-853B-B609ED522339Q34909032-7B32DB74-9043-46FB-A037-1086C8EE3379Q35044195-2151CE1F-F97E-4711-B25B-0B61E1AFFEDCQ35163931-A02C68C7-6553-4CE6-95F9-89C02B76EFA9Q35742156-DA955975-B57D-47BE-98C1-2771022C8AC5Q35789327-AE0F5E30-D5B3-44DD-9C98-332CFB4B4474Q35872462-D61ECB7B-1C79-4728-B5B1-B542DAE75EFAQ35889130-725608F5-AD4C-432F-A1E3-7F94B4D0DFFCQ36076963-93D7C1D2-D300-47BF-AC58-5D99303EE111Q36120767-C52A13CE-4A5A-4CE2-9C90-14AE2BBA2439Q36252850-2A0C16DD-EE5C-4096-AEA5-14F8A0C91765Q36324551-2591B9B6-00BC-49A6-9205-C0924CDB6EC4Q36614208-652B1E92-1316-4E21-B3C2-73A3AE20B47AQ36662104-C23BAC82-A0D0-45A3-80A5-66478B95B2FCQ36666882-80A0D85E-7870-4906-818A-5420ACE1E63EQ36730061-C1E771B4-F0DC-4152-BD28-A9CB43FCBAAA
P2860
The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex.
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The antiinflammatory sesquiter ...... the I kappa B kinase complex.
@ast
The antiinflammatory sesquiter ...... the I kappa B kinase complex.
@en
The antiinflammatory sesquiter ...... the I kappa B kinase complex.
@nl
type
label
The antiinflammatory sesquiter ...... the I kappa B kinase complex.
@ast
The antiinflammatory sesquiter ...... the I kappa B kinase complex.
@en
The antiinflammatory sesquiter ...... the I kappa B kinase complex.
@nl
prefLabel
The antiinflammatory sesquiter ...... the I kappa B kinase complex.
@ast
The antiinflammatory sesquiter ...... the I kappa B kinase complex.
@en
The antiinflammatory sesquiter ...... the I kappa B kinase complex.
@nl
P2093
P1476
The antiinflammatory sesquiter ...... g the I kappa B kinase complex
@en
P2093
M L Schmitz
S P Hehner
T G Hofmann
P304
P407
P577
1999-11-01T00:00:00Z