gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells
about
Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disordersSoluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responsesLhx2 expression promotes self-renewal of a distinct multipotential hematopoietic progenitor cell in embryonic stem cell-derived embryoid bodiesHematopoietic progenitor cells and interleukin-stimulated endothelium: expansion and differentiation of myeloid precursors.Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors.Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver.Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15.Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells.The therapeutic potential of interleukin-6 hyperagonists and antagonists.Cord blood-derived hematopoietic stem/progenitor cells: current challenges in engraftment, infection, and ex vivo expansion.Novel therapy for Crohn's disease targeting IL-6 signalling.The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice.Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity.STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cellsPore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide.Interleukins and cancer immunotherapy.Chimeric cytokine receptor can transduce expansion signals in interleukin 6 receptor alpha (IL-6Ralpha)-, IL-11Ralpha-, and gp130-low to -negative primitive hematopoietic progenitors.Bypassing antibiotic selection: positive screening of genetically modified cells with an antigen-dependent proliferation switch.Erythroid progenitors differentiate and mature in response to endogenous erythropoietin.Expansion of human NOD/SCID-repopulating cells by stem cell factor, Flk2/Flt3 ligand, thrombopoietin, IL-6, and soluble IL-6 receptor.Inhibitory effect of interleukin 3 on early development of human B-lymphopoiesis.Expression of interleukin-6 (IL-6) receptor gene in acute myeloblastic leukemia and response of leukemic cells to exogenous IL-6. A comparative study between cell line cells and corresponding native cells.A combination of stem cell factor and granulocyte colony-stimulating factor enhances the growth of human progenitor B cells supported by murine stromal cell line MS-5.gp130 transducing receptor cross-linking is sufficient to induce interleukin-6 type responses.Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice.Erythropoietin-independent erythrocyte production: signals through gp130 and c-kit dramatically promote erythropoiesis from human CD34+ cells.Analysis of interleukin 6 receptor and gp130 expressions and proliferative capability of human CD34+ cells.Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice.Optimization of culture conditions to enhance transfection of human CD34+ cells by electroporation.Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome.Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells.Murine serum obtained from bone marrow-transplanted mice promotes the proliferation of hematopoietic stem cells by co-culture with MS-5 murine stromal cells.Ontogeny-associated changes in the cytokine responses of primitive human haemopoietic cells.Preferential expression of the vasoactive intestinal peptide (VIP) receptor VPAC1 in human cord blood-derived CD34+CD38- cells: possible role of VIP as a growth-promoting factor for hematopoietic stem/progenitor cells.Competent dendritic cells derived from CD34+ progenitors express CMRF-44 antigen early in the differentiation pathway.
P2860
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P2860
gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells
description
1995 nî lūn-bûn
@nan
1995 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի մարտին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
gp130 and c-Kit signalings syn ...... e hemopoietic progenitor cells
@ast
gp130 and c-Kit signalings syn ...... e hemopoietic progenitor cells
@en
gp130 and c-Kit signalings syn ...... e hemopoietic progenitor cells
@nl
type
label
gp130 and c-Kit signalings syn ...... e hemopoietic progenitor cells
@ast
gp130 and c-Kit signalings syn ...... e hemopoietic progenitor cells
@en
gp130 and c-Kit signalings syn ...... e hemopoietic progenitor cells
@nl
prefLabel
gp130 and c-Kit signalings syn ...... e hemopoietic progenitor cells
@ast
gp130 and c-Kit signalings syn ...... e hemopoietic progenitor cells
@en
gp130 and c-Kit signalings syn ...... e hemopoietic progenitor cells
@nl
P2093
P2860
P356
P1476
gp130 and c-Kit signalings syn ...... e hemopoietic progenitor cells
@en
P2093
Ikebuchi K
Kishimoto T
Yasukawa K
P2860
P304
P356
10.1073/PNAS.92.7.2859
P407
P577
1995-03-01T00:00:00Z