Binding of neomycin-class aminoglycoside antibiotics to mutant ribosomes with alterations in the A site of 16S rRNA.
about
Allosteric control of the ribosome by small-molecule antibiotics.A structural basis for the antibiotic resistance conferred by an A1408G mutation in 16S rRNA and for the antiprotozoal activity of aminoglycosidesCrystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sitesGenetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and TrypanosomaMolecular dynamics study of the ribosomal A-site.Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity.Search for novel aminoglycosides by combining fragment-based virtual screening and 3D-QSAR scoringNew trends in aminoglycosides use.Understanding the origins of bacterial resistance to aminoglycosides through molecular dynamics mutational study of the ribosomal A-site.Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance.Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.Sublethal concentrations of the aminoglycoside amikacin interfere with cell division without affecting chromosome dynamics.External guide sequences targeting the aac(6')-Ib mRNA induce inhibition of amikacin resistance.Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directionsAntimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.Structure-activity relationships among the kanamycin aminoglycosides: role of ring I hydroxyl and amino groupsA novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction.Interaction of aminoglycosides with human mitochondrial 12S rRNA carrying the deafness-associated mutation.The development of FtsZ inhibitors as potential antibacterial agents.Phylogenetic sequence variations in bacterial rRNA affect species-specific susceptibility to drugs targeting protein synthesis.N6', N6''', and O4' Modifications to Neomycin Affect Ribosomal Selectivity without Compromising Antibacterial Activity.Eukaryotic ribosomal RNA determinants of aminoglycoside resistance and their role in translational fidelity.Tobramycin Variants with Enhanced Ribosome-Targeting ActivityMutant A1555G mitochondrial 12S rRNA and aminoglycoside susceptibility.Destination of aminoglycoside antibiotics in the 'post-antibiotic era'.
P2860
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P2860
Binding of neomycin-class aminoglycoside antibiotics to mutant ribosomes with alterations in the A site of 16S rRNA.
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Binding of neomycin-class amin ...... ons in the A site of 16S rRNA.
@ast
Binding of neomycin-class amin ...... ons in the A site of 16S rRNA.
@en
Binding of neomycin-class amin ...... ons in the A site of 16S rRNA.
@nl
type
label
Binding of neomycin-class amin ...... ons in the A site of 16S rRNA.
@ast
Binding of neomycin-class amin ...... ons in the A site of 16S rRNA.
@en
Binding of neomycin-class amin ...... ons in the A site of 16S rRNA.
@nl
prefLabel
Binding of neomycin-class amin ...... ons in the A site of 16S rRNA.
@ast
Binding of neomycin-class amin ...... ons in the A site of 16S rRNA.
@en
Binding of neomycin-class amin ...... ons in the A site of 16S rRNA.
@nl
P2093
P2860
P1476
Binding of neomycin-class amin ...... ons in the A site of 16S rRNA.
@en
P2093
Boris François
Christian Bruell
Eric Westhof
Peter Pfister
Peter Sander
Sven N Hobbie
P2860
P304
P356
10.1128/AAC.50.4.1489-1496.2006
P407
P577
2006-04-01T00:00:00Z