Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin - Wikidata - wikimedia - TriplyDB

Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

http://www.wikidata.org/entity/Q34513299

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Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.Human Mcm proteins at a replication origin during the G1 to S phase transition Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding Geminin regulates neuronal differentiation by antagonizing Brg1 activity Making sense of eukaryotic DNA replication origins.Regulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidization The chromosome cycle: coordinating replication and segregation. Second in the cycles review series.Regulation of replication licensing by acetyltransferase Hbo1.Human cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellular DNA replication.Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damage A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint Geminin promotes neural fate acquisition of embryonic stem cells by maintaining chromatin in an accessible and hyperacetylated state Prevention of DNA re-replication in eukaryotic cells Replication licensing and cancer--a fatal entanglement?Preventing re-replication of chromosomal DNA.The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles Loss of Geminin induces rereplication in the presence of functional p53 The Croonian Lecture 2001 hunting the antisocial cancer cell: MCM proteins and their exploitation Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression Optimisation of the two-dimensional gel electrophoresis protocol using the Taguchi approach Functional domains of the Xenopus replication licensing factor Cdt1 Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts Spatial distribution and specification of mammalian replication origins during G1 phase.Mechanisms for initiating cellular DNA replication Genomic instability in cancer.Replication proteins and human disease Structure of the Cdt1 C-terminal domain: Conservation of the winged helix fold in replication licensing factors Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing Structural basis for homeodomain recognition by the cell-cycle regulator Geminin The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing Two mcm3 mutations affect different steps in the initiation of DNA replication.

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Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

http://www.wikidata.org/entity/Q34513299

description

2001 nî lūn-bûn

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2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2001 թվականի փետրվարին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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name

Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

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Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

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Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

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Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

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Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

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Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

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prefLabel

Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

@ast

Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

@en

Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

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Nature Cell Biology

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Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

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A Li

http://www.w3.org/2001/XMLSchema#string

M Méchali

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S Tada

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P2860

Geminin, an inhibitor of DNA replication, is degraded during mitosis

Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase

A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex

The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins

Drosophila double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts

Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6

Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2

Uninterrupted MCM2-7 function required for DNA replication fork progression.

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107-113

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scholarly article

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10.1038/35055000

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2

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3

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Domenico Maiorano

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2001-02-01T00:00:00Z

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1021402428

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11175741

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3605706

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