Complete human gene structure of obscurin: implications for isoform generation by differential splicing.
about
Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurinMechanoenzymatics of titin kinase.Obscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-lineDifferent obscurin isoforms localize to distinct sites at sarcomeresLarge isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegansThe kinase domains of obscurin interact with intercellular adhesion proteinsGiant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunitThe SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle.A LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle.Developmental expression and differential cellular localization of obscurin and obscurin-associated kinase in cardiac muscle cells.Loss of giant obscurins promotes breast epithelial cell survival through apoptotic resistanceMolecular structure of sarcomere-to-membrane attachment at M-Lines in C. elegans muscleObscure functions: the location-function relationship of obscurins.Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum.Electrostatic interactions mediate binding of obscurin to small ankyrin 1: biochemical and molecular modeling studies.Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cellsEarly incorporation of obscurin into nascent sarcomeres: implication for myofibril assembly during cardiac myogenesisMuscle giants: molecular scaffolds in sarcomerogenesis.Obscurins: Goliaths and Davids take over non-muscle tissues.Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis.OBSCN Mutations Associated with Dilated Cardiomyopathy and Haploinsufficiency.UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.The function of the M-line protein obscurin in controlling the symmetry of the sarcomere in the flight muscle of Drosophila.Titin and obscurin: giants holding hands and discovery of a new Ig domain subsetObscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity.A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegansObscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly.Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection.Ankyrin protein networks in membrane formation and stabilization.Cytoskeletal protein kinases: titin and its relations in mechanosensing.Obscurins: unassuming giants enter the spotlight.Myofilaments: Movers and Rulers of the Sarcomere.Obscurin variants and inherited cardiomyopathies.Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness.Exercise-induced alterations and loss of sarcomeric M-line organization in the diaphragm muscle of obscurin knockout mice.Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway.A comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis.The potential of obscurin as a therapeutic target in muscle disorders.Deletion of small ankyrin 1 (sAnk1) isoforms results in structural and functional alterations in aging skeletal muscle fibers.
P2860
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P2860
Complete human gene structure of obscurin: implications for isoform generation by differential splicing.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Complete human gene structure ...... tion by differential splicing.
@ast
Complete human gene structure ...... tion by differential splicing.
@en
Complete human gene structure ...... tion by differential splicing.
@nl
type
label
Complete human gene structure ...... tion by differential splicing.
@ast
Complete human gene structure ...... tion by differential splicing.
@en
Complete human gene structure ...... tion by differential splicing.
@nl
prefLabel
Complete human gene structure ...... tion by differential splicing.
@ast
Complete human gene structure ...... tion by differential splicing.
@en
Complete human gene structure ...... tion by differential splicing.
@nl
P1476
Complete human gene structure ...... ation by differential splicing
@en
P2093
Atsushi Fukuzawa
Seraphina Idowu
P2888
P304
P356
10.1007/S10974-005-9025-6
P577
2005-01-01T00:00:00Z
P6179
1012771631