Alpha-1-antitrypsin-Pittsburgh. A potent inhibitor of human plasma factor XIa, kallikrein, and factor XIIf.
about
Identification of a new P1 residue mutation (444Arg----Ser) in a dysfunctional C1 inhibitor protein contained in a type II hereditary angioedema plasmaAlpha1-antitrypsin deficiency. 2: genetic aspects of alpha(1)-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema riskRetention of thrombin inhibitory activity by recombinant serpins expressed as integral membrane proteins tethered to the surface of mammalian cells.Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition.Inhibition of IL-32 activation by α-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model.Protection by recombinant alpha 1-antitrypsin Ala357 Arg358 against arterial hypotension induced by factor XII fragment.Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase.Recombinant alpha 1-antitrypsin Pittsburgh attenuates experimental gram-negative septicemiaalpha(1)-Proteinase inhibitor mutants with specificity for plasma kallikrein and C1s but not C1Alpha1-antitrypsin Pittsburgh in a family with bleeding tendency.Phage display of the serpin alpha-1 proteinase inhibitor randomized at consecutive residues in the reactive centre loop and biopanned with or without thrombin.Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease.Met 358 to Arg mutation of alpha 1-antitrypsin associated with protein C deficiency in a patient with mild bleeding tendency.Detection of a new mutant alpha-1-antichymotrypsin in patients with occlusive-cerebrovascular disease.Role of the P2 residue of human alpha 1-antitrypsin in determining target protease specificity.Dysfunctional C1-inhibitor(At), isolated from a type II hereditary-angio-oedema plasma, contains a P1 'reactive centre' (Arg444----His) mutation.Mapping the serpin-proteinase complex using single cysteine variants of alpha1-proteinase inhibitor Pittsburgh.α1 -antitrypsin Pittsburgh and plasmin-mediated proteolysis.
P2860
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P2860
Alpha-1-antitrypsin-Pittsburgh. A potent inhibitor of human plasma factor XIa, kallikrein, and factor XIIf.
description
1986 nî lūn-bûn
@nan
1986 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1986 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
name
Alpha-1-antitrypsin-Pittsburgh ...... , kallikrein, and factor XIIf.
@ast
Alpha-1-antitrypsin-Pittsburgh ...... , kallikrein, and factor XIIf.
@en
Alpha-1-antitrypsin-Pittsburgh ...... , kallikrein, and factor XIIf.
@nl
type
label
Alpha-1-antitrypsin-Pittsburgh ...... , kallikrein, and factor XIIf.
@ast
Alpha-1-antitrypsin-Pittsburgh ...... , kallikrein, and factor XIIf.
@en
Alpha-1-antitrypsin-Pittsburgh ...... , kallikrein, and factor XIIf.
@nl
prefLabel
Alpha-1-antitrypsin-Pittsburgh ...... , kallikrein, and factor XIIf.
@ast
Alpha-1-antitrypsin-Pittsburgh ...... , kallikrein, and factor XIIf.
@en
Alpha-1-antitrypsin-Pittsburgh ...... , kallikrein, and factor XIIf.
@nl
P2093
P2860
P356
P1476
Alpha-1-antitrypsin-Pittsburgh ...... , kallikrein, and factor XIIf.
@en
P2093
C B Glaser
F Kueppers
R W Carrell
R W Colman
P2860
P304
P356
10.1172/JCI112346
P407
P577
1986-02-01T00:00:00Z