Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase.
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SP-A binds alpha1-antitrypsin in vitro and reduces the association rate constant for neutrophil elastase.Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapyHistone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of α1-antitrypsin deficiencyAlpha1-antitrypsin deficiency. 2: genetic aspects of alpha(1)-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema riskAlpha-1-antitrypsin deficiencyDeficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin DeficiencyDiscovery of an inhibitor of Z-alpha1 antitrypsin polymerizationSerine proteinase inhibitor therapy in alpha(1)-antitrypsin inhibitor deficiency and cystic fibrosis.Alpha-1 Antitrypsin and Lung Cell Apoptosis.Fate of aerosolized recombinant DNA-produced alpha 1-antitrypsin: use of the epithelial surface of the lower respiratory tract to administer proteins of therapeutic importance.The significance of the F variant of alpha-1-antitrypsin and unique case report of a PiFF homozygoteAnti-neutrophil elastase defense of the normal human respiratory epithelial surface provided by the secretory leukoprotease inhibitor.Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophagesAlpha 1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy.The role of bronchial epithelial cells in the pathogenesis of COPD in Z-alpha-1 antitrypsin deficiencyα₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts.The role of neutrophils in the pathogenesis of obliterative bronchiolitis after lung transplantation.α1-Antitrypsin activates protein phosphatase 2A to counter lung inflammatory responses.α-1-antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease.Why has it been so difficult to prove the efficacy of alpha-1-antitrypsin replacement therapy? Insights from the study of disease pathogenesisCharacterization of the gene and protein of the common alpha 1-antitrypsin normal M2 allelePractical genetics: alpha-1-antitrypsin deficiency and the serpinopathies.Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivoAlpha1-antitrypsin deficiency. 4: Molecular pathophysiologyQuantitation of circulating wild-type alpha-1-antitrypsin in heterozygous carriers of the S and Z deficiency allelesScavenger receptor class B, type I-mediated uptake of A1AT by pulmonary endothelial cellsA single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activityConformational properties of the disease-causing Z variant of α1-antitrypsin revealed by theory and experiment.The selective advantage of alpha1-antitrypsin deficiency.Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization.Endotoxin receptor CD14 in PiZ alpha-1-antitrypsin deficiency individuals.Molecular basis of alpha 1-antitrypsin deficiency and emphysema associated with the alpha 1-antitrypsin Mmineral springs allele.Molecular Mechanism of Z α1-Antitrypsin DeficiencyChemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency.A monoclonal antibody (MCPR3-7) interfering with the activity of proteinase 3 by an allosteric mechanism.Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. Role of surface proteinase-3, alpha1-antitrypsin, and Fcgamma receptors.Inhibition of intracellular degradation increases secretion of a mutant form of alpha1-antitrypsin associated with profound deficiency.alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies.Augmentation therapy in alpha-1 antitrypsin deficiency: advances and controversies.Molecular diagnostics of α1-antitrypsin deficiency.
P2860
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P2860
Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
1987年论文
@zh
1987年论文
@zh-cn
name
Z-type alpha 1-antitrypsin is ...... ibitor of neutrophil elastase.
@ast
Z-type alpha 1-antitrypsin is ...... ibitor of neutrophil elastase.
@en
type
label
Z-type alpha 1-antitrypsin is ...... ibitor of neutrophil elastase.
@ast
Z-type alpha 1-antitrypsin is ...... ibitor of neutrophil elastase.
@en
prefLabel
Z-type alpha 1-antitrypsin is ...... ibitor of neutrophil elastase.
@ast
Z-type alpha 1-antitrypsin is ...... ibitor of neutrophil elastase.
@en
P2093
P2860
P356
P1476
Z-type alpha 1-antitrypsin is ...... ibitor of neutrophil elastase.
@en
P2093
P2860
P304
P356
10.1172/JCI113214
P407
P577
1987-11-01T00:00:00Z