Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse.
about
Megsin gene: its genomic analysis, pathobiological functions, and therapeutic perspectivesUsing Drosophila to discover mechanisms underlying type 2 diabetesAdvancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient miceINS-gene mutations: from genetics and beta cell biology to clinical diseaseCrystal Structure of a"Nonfoldable"Insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITYGenomewide analysis reveals novel pathways affecting endoplasmic reticulum homeostasis, protein modification and quality control.Protective mechanisms of mitochondria and heart function in diabetesThe unfolded protein response in immunity and inflammationChiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chainHuman allograft rejection in humanized mice: a historical perspectiveTransgenic zebrafish model of the C43G human insulin gene mutationSpontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1Apoptosis-inducing signal sequence mutation in carbonic anhydrase IV identified in patients with the RP17 form of retinitis pigmentosa.Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family.Humanized mouse models to study human diseasesDeciphering a molecular mechanism of neonatal diabetes mellitus by the chemical synthesis of a protein diastereomer, [D-AlaB8]human proinsulin.Deciphering the hidden informational content of protein sequences: foldability of proinsulin hinges on a flexible arm that is dispensable in the mature hormoneGenetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation.Proinsulin and the genetics of diabetes mellitusEffect of insulin and an erythropoietin-derived peptide (ARA290) on established neuritic dystrophy and neuronopathy in Akita (Ins2 Akita) diabetic mouse sympathetic ganglia.Use of Humanized Mice to Study the Pathogenesis of Autoimmune and Inflammatory DiseasesThe role of endoplasmic reticulum stress in autoimmune-mediated beta-cell destruction in type 1 diabetes.The structure and function of insulin: decoding the TR transitionInsulin gene mutations as a cause of permanent neonatal diabetes.Proinsulin maturation, misfolding, and proteotoxicity.A Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein.Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response.ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus.Potential for therapeutic manipulation of the UPR in disease.Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3β-dependent inhibition of apoptosis and ER stressProinsulin disulfide maturation and misfolding in the endoplasmic reticulumType 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.Diabetes mellitus due to the toxic misfolding of proinsulin variants.Humanized mice for the study of type 1 diabetes and beta cell functionPro370Leu mutant myocilin disturbs the endoplasm reticulum stress response and mitochondrial membrane potential in human trabecular meshwork cells.Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits.Neuritic dystrophy and neuronopathy in Akita (Ins2(Akita)) diabetic mouse sympathetic gangliaHLA-B27 misfolding and spondyloarthropathies.The endoplasmic reticulum stress response in immunity and autoimmunity.
P2860
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P2860
Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse.
description
2002 nî lūn-bûn
@nan
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse.
@ast
Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse.
@en
Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse.
@nl
type
label
Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse.
@ast
Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse.
@en
Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse.
@nl
prefLabel
Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse.
@ast
Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse.
@en
Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse.
@nl
P2860
P356
P1476
Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse.
@en
P2860
P304
P356
10.1172/JCI0215020
P407
P50
P577
2002-02-01T00:00:00Z