about
INS-gene mutations: from genetics and beta cell biology to clinical diseaseCrystal Structure of a"Nonfoldable"Insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITYStimulation of autophagy improves endoplasmic reticulum stress-induced diabetesERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasisFructose: it's "alcohol without the buzz".Characterization of 5-(2- 18F-fluoroethoxy)-L-tryptophan for PET imaging of the pancreas.An islet in distress: β cell failure in type 2 diabetes.Misfolded proinsulin affects bystander proinsulin in neonatal diabetesTransgenic zebrafish model of the C43G human insulin gene mutationEndoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin.Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention.Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family.Inefficient translocation of preproinsulin contributes to pancreatic β cell failure and late-onset diabetes.Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transportIn vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes.Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis.Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function.Hyperglucagonemia in an animal model of insulin- deficient diabetes: what therapy can improve it?PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.Deciphering the hidden informational content of protein sequences: foldability of proinsulin hinges on a flexible arm that is dispensable in the mature hormoneProinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth.Unraveling the contribution of pancreatic beta-cell suicide in autoimmune type 1 diabetes.Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin.A model of threshold behavior reveals rescue mechanisms of bystander proteins in conformational diseasesProinsulin and the genetics of diabetes mellitusProinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes.Structural analysis of proinsulin hexamer assembly by hydroxyl radical footprinting and computational modelingThe structure and function of insulin: decoding the TR transitionImpaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetesCOPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis.Revisiting PC1/3 Mutants: Dominant-Negative Effect of Endoplasmic Reticulum-Retained Mutants.PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis.Proinsulin intermolecular interactions during secretory trafficking in pancreatic β cellsThe unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetesChop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux.Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes.Diabetes mellitus due to the toxic misfolding of proinsulin variants.Endoplasmic reticulum oxidoreductin-1α (Ero1α) improves folding and secretion of mutant proinsulin and limits mutant proinsulin-induced endoplasmic reticulum stress.Autoimmunity and the pathogenesis of type 1 diabetes.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Proinsulin maturation, misfolding, and proteotoxicity.
@ast
Proinsulin maturation, misfolding, and proteotoxicity.
@en
type
label
Proinsulin maturation, misfolding, and proteotoxicity.
@ast
Proinsulin maturation, misfolding, and proteotoxicity.
@en
prefLabel
Proinsulin maturation, misfolding, and proteotoxicity.
@ast
Proinsulin maturation, misfolding, and proteotoxicity.
@en
P2093
P2860
P356
P1476
Proinsulin maturation, misfolding, and proteotoxicity.
@en
P2093
Christopher J Rhodes
Israel Hodish
Peter Arvan
P2860
P304
15841-15846
P356
10.1073/PNAS.0702697104
P407
P577
2007-09-26T00:00:00Z