Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. - Wikidata - wikimedia - TriplyDB

Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.

Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.

http://www.wikidata.org/entity/Q34550115

about

Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining XRCC4's interaction with XLF is required for coding (but not signal) end joining The response to and repair of RAG-mediated DNA double-strand breaks Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells.Methotrexate inhibits NF-κB activity via long intergenic (noncoding) RNA-p21 induction Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining.All stressed out without ATM kinase Overlapping functions between XLF repair protein and 53BP1 DNA damage response factor in end joining and lymphocyte development Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice Integrated signaling in developing lymphocytes: the role of DNA damage responses.Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining.Lymphocyte development: integration of DNA damage response signaling.Non-homologous end joining repair in Xenopus egg extract Functional overlaps between XLF and the ATM-dependent DNA double strand break response.Kruppel-associated box (KRAB) proteins in the adaptive immune system.Programmed DNA breaks in lymphoid cells: repair mechanisms and consequences in human disease Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites.TDP1 promotes assembly of non-homologous end joining protein complexes on DNA.Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytes.CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitro.Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70.RNA-binding protein RBM14 regulates dissociation and association of non-homologous end joining proteins.

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Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.

http://www.wikidata.org/entity/Q34550115

description

2011 nî lūn-bûn

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Ataxia telangiectasia mutated ...... osomal signal joint formation.

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Ataxia telangiectasia mutated ...... osomal signal joint formation.

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type

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Ataxia telangiectasia mutated ...... osomal signal joint formation.

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Ataxia telangiectasia mutated ...... osomal signal joint formation.

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Ataxia telangiectasia mutated ...... osomal signal joint formation.

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Ataxia telangiectasia mutated ...... osomal signal joint formation.

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PNAS.1013295108

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Proceedings of the National Academy of Sciences of the United States of America

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Ataxia telangiectasia mutated ...... osomal signal joint formation.

@en

P2093

Andre Nussenzweig

http://www.w3.org/2001/XMLSchema#string

Andrea Bredemeyer

http://www.w3.org/2001/XMLSchema#string

Barry P Sleckman

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Bu Yin

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Craig H Bassing

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Elsa Callen

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Eric J Gapud

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Grace K Mahowald

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Jeffrey J Bednarski

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Kazuo Q Omi

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P2860

Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination

Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes

Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.

Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system.

The DNA damage response: putting checkpoints in perspective

Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

The RAG proteins and V(D)J recombination: complexes, ends, and transposition

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

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2022-2027

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10.1073/PNAS.1013295108

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