Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils
about
Multiple roles for the actin cytoskeleton during regulated exocytosisRegulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectorsMunc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responsesDiacylglycerol Kinases in T Cell Tolerance and Effector FunctionVesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.Upregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress, and reduces lysosome overload in cystinosis.Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane.MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membraneMunc13-4 functions as a Ca2+ sensor for homotypic secretory granule fusion to generate endosomal exocytic vacuoles.Munc13-4*rab27 complex tethers secretory lysosomes at the plasma membrane.MUNC13-4 protein regulates the oxidative response and is essential for phagosomal maturation and bacterial killing in neutrophils.Regulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and FunctionA network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils.Familial hemophagocytic lymphohistiocytosis: when rare diseases shed light on immune system functioning.Rab27A regulates transport of cell surface receptors modulating multinucleation and lysosome-related organelles in osteoclasts.Rab27 effectors, pleiotropic regulators in secretory pathways.Late steps in secretory lysosome exocytosis in cytotoxic lymphocytes.The role of Rab27a in the regulation of neutrophil function.The biogenesis of lysosomes and lysosome-related organellesIncreased survival and reduced neutrophil infiltration of the liver in Rab27a- but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation.Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation.Role of Munc13-4 as a Ca2+-dependent tether during platelet secretion.Presynaptic morphology and vesicular composition determine vesicle dynamics in mouse central synapses.Different Munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes.Neutrophil azurophilic granule exocytosis is primed by TNF-α and partially regulated by NADPH oxidase.Armed for destruction: formation, function and trafficking of neutrophil granules.Frontline Science: Tumor necrosis factor-α stimulation and priming of human neutrophil granule exocytosis.Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis.
P2860
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P2860
Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils
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2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Munc13-4 restricts motility of ...... g of exocytosis in neutrophils
@ast
Munc13-4 restricts motility of ...... g of exocytosis in neutrophils
@en
Munc13-4 restricts motility of ...... g of exocytosis in neutrophils
@nl
type
label
Munc13-4 restricts motility of ...... g of exocytosis in neutrophils
@ast
Munc13-4 restricts motility of ...... g of exocytosis in neutrophils
@en
Munc13-4 restricts motility of ...... g of exocytosis in neutrophils
@nl
prefLabel
Munc13-4 restricts motility of ...... g of exocytosis in neutrophils
@ast
Munc13-4 restricts motility of ...... g of exocytosis in neutrophils
@en
Munc13-4 restricts motility of ...... g of exocytosis in neutrophils
@nl
P2093
P2860
P356
P1476
Munc13-4 restricts motility of ...... g of exocytosis in neutrophils
@en
P2093
Jennifer L Johnson
Jlenia Monfregola
William B Kiosses
P2860
P304
P356
10.1074/JBC.M110.184762
P407
P577
2010-12-09T00:00:00Z