Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: mapping of Emca1 and Emca2 to chromosomes 5 and 18.
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Ept7 influences estrogen action in the pituitary gland and body weight of ratsSignificant overlap between human genome-wide association-study nominated breast cancer risk alleles and rat mammary cancer susceptibility loci.Physical Confirmation and Comparative Genomics of the Rat Mammary carcinoma susceptibility 3 Quantitative Trait LocusMap making in the 21st century: charting breast cancer susceptibility pathways in rodent models.Validation of six genetic determinants of susceptibility to estrogen-induced mammary cancer in the rat and assessment of their relevance to breast cancer risk in humansIdentification of novel carcinogen-mediated mammary tumor susceptibility loci in the rat using the chromosome substitution technique.Genetic bases of estrogen-induced pituitary tumorigenesis: identification of genetic loci determining estrogen-induced pituitary growth in reciprocal crosses between the ACI and Copenhagen rat strainsMultiple susceptibility loci for radiation-induced mammary tumorigenesis in F2[Dahl S x R]-intercross rats.Association of cellular and molecular responses in the rat mammary gland to 17β-estradiol with susceptibility to mammary cancerGenetic etiology of renal agenesis: fine mapping of Renag1 and identification of Kit as the candidate functional geneAssessing estrogen signaling aberrations in breast cancer risk using genetically engineered mouse models.Development and characterization of a novel rat model of estrogen-induced mammary cancer.NO to breast: when, why and why not?Tamoxifen induces regression of estradiol-induced mammary cancer in the ACI.COP-Ept2 rat model.Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene.Mapping of three genetic determinants of susceptibility to estrogen-induced mammary cancer within the Emca8 locus on rat chromosome 5.Tissue-specific actions of the Ept1, Ept2, Ept6, and Ept9 genetic determinants of responsiveness to estrogens in the female rat.Exposure to estrogen and ionizing radiation causes epigenetic dysregulation, activation of mitogen-activated protein kinase pathways, and genome instability in the mammary gland of ACI rats.Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc(Min/+) mice.Rat Models of 17beta-Estradiol-Induced Mammary Cancer Reveal Novel Insights into Breast Cancer Etiology and Prevention.Sulforaphene inhibits triple negative breast cancer through activating tumor suppressor Egr1.Isolation of two regions on rat chromosomes 5 and 18 affecting mammary cancer susceptibility.Estrogen receptor-alpha deficiency attenuates autoimmune disease in (NZB x NZW)F1 mice.Susceptibility loci affecting ERBB2/neu-induced mammary tumorigenesis in mice.Rebuttal of "Flawed Experimental Design Reveals the Need for Guidelines Requiring Appropriate Positive Controls in Endocrine Disruption Research" by (Vom Saal 2010).Genetic variation in sensitivity to estrogens and breast cancer risk.Ept7, a quantitative trait locus that controls estrogen-induced pituitary lactotroph hyperplasia in rat, is orthologous to a locus in humans that has been associated with numerous cancer types and common diseases
P2860
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P2860
Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: mapping of Emca1 and Emca2 to chromosomes 5 and 18.
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2004 nî lūn-bûn
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2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2004年の論文
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2004年論文
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2004年論文
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2004年論文
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2004年論文
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2004年論文
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2004年论文
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Genetic determination of susce ...... Emca2 to chromosomes 5 and 18.
@ast
Genetic determination of susce ...... Emca2 to chromosomes 5 and 18.
@en
Genetic determination of susce ...... Emca2 to chromosomes 5 and 18.
@nl
type
label
Genetic determination of susce ...... Emca2 to chromosomes 5 and 18.
@ast
Genetic determination of susce ...... Emca2 to chromosomes 5 and 18.
@en
Genetic determination of susce ...... Emca2 to chromosomes 5 and 18.
@nl
prefLabel
Genetic determination of susce ...... Emca2 to chromosomes 5 and 18.
@ast
Genetic determination of susce ...... Emca2 to chromosomes 5 and 18.
@en
Genetic determination of susce ...... Emca2 to chromosomes 5 and 18.
@nl
P2093
P2860
P1433
P1476
Genetic determination of susce ...... Emca2 to chromosomes 5 and 18.
@en
P2093
Beverly S Schaffer
Clare R Murrin
Cynthia M Lachel
Eric A VanderWoude
James D Shull
Jane L Meza
Karen A Gould
Karen L Pennington
Kimberly K Bynote
Lisa A Flood
P2860
P304
P356
10.1534/GENETICS.104.033878
P407
P577
2004-12-01T00:00:00Z