Discovery and development of clofarabine: a nucleoside analogue for treating cancer. - Wikidata - wikimedia - TriplyDB

Discovery and development of clofarabine: a nucleoside analogue for treating cancer.

Discovery and development of clofarabine: a nucleoside analogue for treating cancer.

http://www.wikidata.org/entity/Q34571029

about

Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer Treating refractory leukemias in childhood, role of clofarabine Physiological and pathological implications of 5-hydroxymethylcytosine in diseases Fifty years of melphalan use in hematopoietic stem cell transplantation Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase X-ray Scattering Studies of Protein Structural Dynamics.Treating adults with acute lymphocytic leukemia: new pharmacotherapy options.Oral clofarabine for relapsed/refractory non-Hodgkin lymphomas: results of a phase 1 study Phase 1 study of clofarabine in pediatric patients with relapsed/refractory acute lymphoblastic leukemia in Japan.Polyadenylation inhibition by the triphosphates of deoxyadenosine analogues.Simultaneous determination of fludarabine and clofarabine in human plasma by LC-MS/MS.The chemoenzymatic synthesis of clofarabine and related 2'-deoxyfluoroarabinosyl nucleosides: the electronic and stereochemical factors determining substrate recognition by E. coli nucleoside phosphorylases.Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity.A randomized study of 2 dose levels of intravenous clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome.Clofarabine: past, present, and future.A fluorimetric readout reporting the kinetics of nucleotide-induced human ribonucleotide reductase oligomerization.Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit Novel PET probes specific for deoxycytidine kinase.DNA repair mechanisms in cancer development and therapy Preclinical examination of clofarabine in pediatric ependymoma: intratumoral concentrations insufficient to warrant further study.New trends in nucleoside biotechnology Valproic acid synergistically enhances the cytotoxicity of clofarabine in pediatric acute myeloid leukemia cells.Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers Stratification of nucleoside analog chemotherapy using 1-(2'-deoxy-2'-18F-fluoro-β-D-arabinofuranosyl)cytosine and 1-(2'-deoxy-2'-18F-fluoro-β-L-arabinofuranosyl)-5-methylcytosine PET.Synthesis, evaluation of anti-HIV-1 and anti-HCV activity of novel 2',3'-dideoxy-2',2'-difluoro-4'-azanucleosides French "real life" experience of clofarabine in children with refractory or relapsed acute lymphoblastic leukaemia.Studies toward the oxidative and reductive activation of C-S bonds in 2'-S-aryl-2'-thiouridine derivatives.Acute myeloid leukaemia: optimal management and recent developments.Oral clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome.Fluorinated Nucleosides: Synthesis and Biological Implication Cladribine and Fludarabine Nucleotides Induce Distinct Hexamers Defining a Common Mode of Reversible RNR Inhibition.Hypermutation of DPYD Deregulates Pyrimidine Metabolism and Promotes Malignant Progression.Inhibition of ATP synthase by chlorinated adenosine analogue.Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases.Older patients with acute myeloid leukemia.New nucleoside analogs for patients with hematological malignancies.Clofarabine for myelodysplastic syndromes.Clofarabine in pediatric acute leukemia: current findings and issues.The prototypic class Ia ribonucleotide reductase from Escherichia coli: still surprising after all these years.

P2860

Q24629752-73C8AF06-3F2B-491E-841E-C8BD4A727830 Q24642847-29275304-1F06-440A-B8BB-74897ABF5C99 Q24647279-EED4B620-27DF-4AB9-BC2B-3E1F6F6F66AC Q26749375-EAA14BDE-E65C-433F-8041-47DAD8E36028 Q26824498-463E969E-C7B4-486D-B9BE-EE7058D95268 Q27681351-2630BE7B-2AC2-4EA0-B53D-7F5E8883CA6F Q30101114-3F9C5084-2188-4BEF-B6EC-BE6C816E9F63 Q30243925-412BE301-41A6-456E-8448-FDB6FEC23D9F Q33405103-E7050F78-D60B-46D3-9A8A-30D9903DED58 Q33431558-17BC2713-973B-4CAD-9C0D-7D9AE3A6712E Q33721126-5A47E305-3A6E-403D-9AB6-C00D3EB1B623 Q33949932-96094445-7F03-463E-8732-C3C8C03F6353 Q34082241-0493F30A-5027-428A-9F08-CE6BE47BB2BE Q34159634-0F488591-8B6C-4251-9515-216838BF9CCE Q34267853-B2F9DF99-9101-4A62-9D5F-9661D4ADB4DB Q34686726-C1B69DCD-1BA0-4655-922B-A9610C1E408D Q34740945-4352E092-7A48-4C80-84E3-610F6C1C7387 Q35049193-EBCDFC53-8005-40CF-960F-CC22A2023976 Q35059531-BD6DAF8E-94D7-4E9C-BCB3-FF6392B2CE81 Q35531287-94026EAE-AD29-48B3-BACF-A8B559DA651E Q35572057-64EFFC07-FDF3-4C1F-997D-8698E20EB181 Q35944327-94B7A75D-8D6A-4613-A753-B6F5E876EE17 Q36094977-23A335E4-F9C5-4339-AA05-25BBCD154CB6 Q36128479-C0A32465-19E3-4907-8EDE-E7C34D589F03 Q36201693-EFDA5C97-A1F0-4514-9096-D0E77B1CD7B0 Q36374005-63587F8A-EA20-4837-A94D-6D1BB125132C Q36689775-7EDA58BE-9C40-4E2C-AFF8-C8828282C4B2 Q36724814-815E21B0-8ADE-4BCA-B784-21A10FEB0AF5 Q36914091-0BBF10C4-D7C1-441A-B97C-796B64F9C8E6 Q36915178-BE2DB39F-BD47-4822-997D-D230DDBE3620 Q36974059-E9B3070D-F7EA-47B4-A6D4-1D5271DD4053 Q37099024-E9CF8034-E263-4C7E-9211-809FE4047084 Q37258328-62E3EBFD-ADAC-4490-B013-4C096A0CEC78 Q37391304-B0C1972C-C3CC-4876-93DC-90AF73AD08D0 Q37424784-0A02BBE0-BD93-4938-B3BE-AA6EAB0907AD Q37810969-44F25FAD-2743-4451-A275-412A4FB8E9BB Q37841589-BF2B585D-04D7-4F8B-9466-F1FCF0CB70A7 Q37876909-9C1E31D3-4EF5-480C-9599-19042B8CE517 Q37987061-8635D500-94A4-448D-A103-6503A6BACAB0 Q38012192-DDB5C145-0060-4D34-B9F0-B4E46629B93D

P2860

Discovery and development of clofarabine: a nucleoside analogue for treating cancer.

http://www.wikidata.org/entity/Q34571029

description

2006 nî lūn-bûn

@nan

2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

Discovery and development of clofarabine: a nucleoside analogue for treating cancer.

@ast

Discovery and development of clofarabine: a nucleoside analogue for treating cancer.

@en

Discovery and development of clofarabine: a nucleoside analogue for treating cancer.

@nl

type

label

Discovery and development of clofarabine: a nucleoside analogue for treating cancer.

@ast

Discovery and development of clofarabine: a nucleoside analogue for treating cancer.

@en

Discovery and development of clofarabine: a nucleoside analogue for treating cancer.

@nl

prefLabel

Discovery and development of clofarabine: a nucleoside analogue for treating cancer.

@ast

Discovery and development of clofarabine: a nucleoside analogue for treating cancer.

@en

Discovery and development of clofarabine: a nucleoside analogue for treating cancer.

@nl

P1433

Q34571029-846939F9-F8E1-466E-8E4E-58EAB7E05D82

P1476

Q34571029-5EBE4D6F-E053-46FF-A60F-A09CDCD65C5B

P2093

Q34571029-0DE151A2-9132-447C-A124-C5B6F5D49EAB

Q34571029-135238BC-4163-44B6-9FEA-1625BF22D4F0

Q34571029-54144669-BEE5-4F0A-844F-66E45A170C41

Q34571029-63866D80-2938-42DF-89EC-FAF32DE0785C

Q34571029-A29C4408-39A6-44AA-AE6C-5C6387E3650F

Q34571029-C00F5975-87AA-4BF4-9EA4-8AC28BFE5E3D

P2860

Q34571029-CB703514-C95D-4D0E-848E-8065EFE6E7CC

P2888

Q34571029-09F57C90-2EBC-4D2E-A796-BA8D65D0B0B5

P304

Q34571029-4CB650D0-465D-437E-84B9-051588C05DCF

P31

Q34571029-21403FD9-F810-4314-9C90-241C4845394E

P356

Q34571029-DFC5A268-9CD5-43DA-82EF-C9663D261D9A

P433

Q34571029-C7826B4D-FD84-4A6D-8621-258B444BBF76

P478

Q34571029-CFEB73B4-CF90-4FB3-B677-44ACFC508385

P577

Q34571029-242973D0-EF38-4402-9999-B79F89EA0857

P5875

Q34571029-1CE0CC7B-53B4-4AE9-AF59-8004C3DFC12E

P698

Q34571029-FEC76946-72DA-4E90-AD6E-FE0892CA5170

P356

P1433

Nature Reviews Drug Discovery

P1476

Discovery and development of clofarabine: a nucleoside analogue for treating cancer.

@en

P2093

John A Secrist

http://www.w3.org/2001/XMLSchema#string

Katherine Stephenson

http://www.w3.org/2001/XMLSchema#string

Larry Arthaud

http://www.w3.org/2001/XMLSchema#string

Peter L Bonate

http://www.w3.org/2001/XMLSchema#string

Steve Weitman

http://www.w3.org/2001/XMLSchema#string

William R Cantrell

http://www.w3.org/2001/XMLSchema#string

P2860

Es nucleoside transporter content of acute leukemia cells: role in cell sensitivity to cytarabine (araC).

P2888

P304

855-863

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NRD2055

http://www.w3.org/2001/XMLSchema#string

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

5

http://www.w3.org/2001/XMLSchema#string

P577

2006-10-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6779542

http://www.w3.org/2001/XMLSchema#string

P698

17016426

http://www.w3.org/2001/XMLSchema#string