A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation.
about
Conservation of sequence in recombination signal sequence spacersRecombinant human natural autoantibodies against GPIIb/IIIa inhibit binding of autoantibodies from patients with AITP.The frequency of homozygous deletion of a developmentally regulated Vh gene (Humhv3005) is increased in patients with chronic idiopathic thrombocytopenic purpura.Segmental duplication as one of the driving forces underlying the diversity of the human immunoglobulin heavy chain variable gene regionPossible deletion of a developmentally regulated heavy-chain variable region gene in autoimmune diseases.Analysis of human antitopoisomerase-I idiotypesDefining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors.Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity.New roles for rheumatoid factor.Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus.Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseasesCovalent binding antibodies suppress advanced glycation: on the innate tier of adaptive immunity.Systematic analysis of sequences of anti-DNA antibodies--relevance to theories of origin and pathogenicity.Haplotypes of the human immunoglobulin lambda IGLV7S1 and IGLV1S1 genes defined by restriction-site polymorphism and insertion/deletion of a 6-kb DNA fragment.Structural and functional properties of human lambda-light-chain variable-region subgroups.Genetic regulation of CD5+ B cells in autoimmune disease and in chronic lymphocytic leukemia.Analysis of human monoclonal antibodies elicited by vaccination with a Cryptococcus neoformans glucuronoxylomannan capsular polysaccharide vaccine.Sequence analyses of three immunoglobulin G anti-virus antibodies reveal their utilization of autoantibody-related immunoglobulin Vh genes, but not V lambda genes.Plasmodium riboprotein PfP0 induces a deviant humoral immune response in Balb/c mice.The human VH repertoire: a restricted set of VH genes may be the target of immune regulation.Human rheumatoid B-1a (CD5+ B) cells make somatically hypermutated high affinity IgM rheumatoid factorsGenetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven responseStructure of the VH and VL segments of polyreactive and monoreactive human natural antibodies to HIV-1 and Escherichia coli beta-galactosidaseHuman anti-self antibodies with high specificity from phage display libraries.Genetic analysis of the variable region genes encoding a monospecific human natural anti-DNA antibody.Examining the non-linear relationship between monoclonal antiphospholipid antibody sequence, structure and function.The biologic significance of human natural autoimmune responses: relationship to the germline, early immune and malignant B cell variable gene repertoire.The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement.Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. Evidence for affinity maturation by somatic hypermutation and repertoire shift.Two acquired immunodeficiency syndrome-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments.Structural analysis of the VH-D-JH segments of human polyreactive IgG mAb. Evidence for somatic selection.Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments.Idiotypic analysis of human anti-topoisomerase I autoantibodies.A human anti-insulin IgG autoantibody apparently arises through clonal selection from an insulin-specific "germ-line" natural antibody template. Analysis by V gene segment reassortment and site-directed mutagenesis.Immunocytochemical detection of kappa and lambda light chain V region subgroups in human B-cell malignancies.Natural polyreactive immunoglobulin A antibodies produced in mouse Peyer's patches.VH usage and somatic hypermutation in peripheral blood B cells of patients with rheumatoid arthritis (RA).Characterization of two human anti-DNA antibodies bearing the pathogenic idiotype 8.12.
P2860
Q28255001-7C8323C0-54F6-44BA-A573-AA5F3874B572Q32031023-D027B8B0-BCFD-42F3-AB1D-D73AAA4B4601Q33499241-38F7BDC4-E4C2-4F61-849C-47FEF36BC26DQ33805553-C0A5DC7D-286C-48CA-9EE9-1A103CBB8FCDQ33838611-5DCF43A7-8705-40F7-9BCA-EBC2B3424725Q33901961-EA339F26-527E-465E-B75E-88FE5AC16877Q34152068-4D662A95-2069-4010-9BCC-0491A18AAA3FQ34161517-9399B2B9-16E9-4153-A762-53EBC7A90BF8Q34179855-8F6932C7-85B4-407E-8344-819591A27811Q34210066-005E8644-ADCB-4F65-A305-EBFB55FCA706Q34225507-19474F9C-829E-4813-9CE3-CA74576F0339Q34287672-4305CB09-51E7-4B77-8896-A1A56616B198Q35045892-1B14EE42-4D29-47EF-9C40-6112525DB4C9Q35194840-646AA088-B4AF-48FA-B652-E31B1337EDF0Q35224586-AE90BD17-0B88-42E1-924A-56E32E3FDD09Q35320964-F5AFEA4A-E17D-417E-B316-7C07D9EA5230Q35428887-D7AA3862-5DC6-4B5D-A214-81A5C6C4A807Q35612673-5900C239-B4B3-46F5-831C-BC1FF2535668Q35725321-27EFB7E3-931D-4EEC-8E9A-C6F104FEFCBAQ36196150-8184D8E2-BF8F-4F31-8172-2706FAE0CC1FQ36222893-BC47DE32-16C2-4058-AEE7-822B8614FF5DQ36231063-AED4D4D4-AD69-4555-AACA-35CF1D1D8A06Q36263296-EE90E4DD-F1CE-4C6F-94E0-86A691B25CA7Q36695237-7F80A05C-9255-427D-B582-2BDF958C349DQ36764375-1133CCCD-F798-44F2-9726-3A3183A44A5AQ37283017-BEC87719-01E0-4E31-BA24-A9BDF10FF483Q37837361-2668CBF5-9EDA-4F8B-A871-200860834851Q40626080-225C8DA8-59FE-4ED2-AA1D-97CEEF7B6958Q41022184-ADDFFB47-2F50-4EA1-8C75-1D92A3996ABBQ41467818-9472BC73-8E1D-48F7-A3FA-7C5892E7E169Q41522864-667ED8BD-92C7-453F-8DAA-B3162DCDEFDBQ41886151-219B4C99-005E-43FB-9E94-B23CEE38D133Q42150981-931AC1B2-32F9-4EAF-A6B1-19DD04A3619DQ42604824-B24033BB-C6AF-4110-8D1E-EF9B88E93029Q42774191-B03DAC8C-350F-43AB-897C-DD9511B7582BQ42799202-0C179EB4-E763-463E-BA5B-59D6BC57915DQ47901365-46F859C9-383F-482F-BB1E-F3C2E9FC702BQ48142878-7EDC67BA-CCB8-44E3-81D4-48A9AC81E44C
P2860
A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation.
description
1989 nî lūn-bûn
@nan
1989 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
A natural autoantibody is enco ...... enes without somatic mutation.
@ast
A natural autoantibody is enco ...... enes without somatic mutation.
@en
A natural autoantibody is enco ...... enes without somatic mutation.
@nl
type
label
A natural autoantibody is enco ...... enes without somatic mutation.
@ast
A natural autoantibody is enco ...... enes without somatic mutation.
@en
A natural autoantibody is enco ...... enes without somatic mutation.
@nl
prefLabel
A natural autoantibody is enco ...... enes without somatic mutation.
@ast
A natural autoantibody is enco ...... enes without somatic mutation.
@en
A natural autoantibody is enco ...... enes without somatic mutation.
@nl
P2093
P2860
P356
P1476
A natural autoantibody is enco ...... enes without somatic mutation.
@en
P2093
K A Siminovitch
P2860
P304
P356
10.1172/JCI114347
P407
P577
1989-11-01T00:00:00Z