Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments.
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Antibody promiscuity: Understanding the paradigm shift in antigen recognitionImmunoglobulin VH-gene usage of autoantibodies in mercuric chloride-induced membranous glomerulopathy in the ratBroad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine targetGeneration of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity.Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic toleranceFolding funnels and binding mechanisms.Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity.The molecular specificity of insulin autoantibodies.Exquisite specificity and peptide epitope recognition promiscuity, properties shared by antibodies from sharks to humans.Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors.Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.Loss of anergic B cells in prediabetic and new-onset type 1 diabetic patients.High Affinity Antibodies against Influenza Characterize the Plasmablast Response in SLE Patients After Vaccination.Autoantibody selection and production in early human life.Recovery of a human natural antibody against the noncollagenous-1 domain of type IV collagen using humanized models.Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies.Monoclonal antibody-based candidate therapeutics against HIV type 1.Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation.Structure-function analysis of a lupus anti-DNA autoantibody: central role of the heavy chain complementarity-determining region 3 Arg in binding of double- and single-stranded DNA.The Number of Overlapping AID Hotspots in Germline IGHV Genes Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia.B-cell tolerance checkpoints in healthy humans and patients with systemic lupus erythematosus.Defective B cell tolerance checkpoints in systemic lupus erythematosusShort-term assessment of BCR repertoires of SLE patients after high dose glucocorticoid therapy with high-throughput sequencingMicroRNAs prevent the generation of autoreactive antibodies.Identification of DNA-reactive B cells in patients with systemic lupus erythematosus.Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligationMolecular mechanisms of autoimmunity.B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidatesHigh Throughput Sequencing of T Cell Antigen Receptors Reveals a Conserved TCR RepertoireNature and functions of autoantibodies.Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells.Cellular targets and mechanistic strategies of remyelination-promoting IgMs as part of the naturally occurring autoantibody repertoire.Differences in the composition of the human antibody repertoire by B cell subsets in the blood.Polyreactive antibodies in adaptive immune responses to viruses.Natural autoantibodies and associated B cells in immunity and autoimmunity.Molecular determinants of polyreactive antibody binding: HCDR3 and cyclic peptides.Current status and recent advances of next generation sequencing techniques in immunological repertoire.Promiscuous antibodies characterised by their physico-chemical properties: From sequence to structure and back.Human monoclonal natural autoantibodies against the T-cell receptor inhibit interleukin-2 production in murine T cells.Molecular structure of eight human autoreactive monoclonal antibodies.
P2860
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P2860
Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Analysis of the structural cor ...... vy and light chain V segments.
@en
type
label
Analysis of the structural cor ...... vy and light chain V segments.
@en
prefLabel
Analysis of the structural cor ...... vy and light chain V segments.
@en
P2860
P356
P1476
Analysis of the structural cor ...... vy and light chain V segments.
@en
P2093
P2860
P304
P356
10.1084/JEM.180.3.885
P407
P577
1994-09-01T00:00:00Z