CUL4A overexpression enhances lung tumor growth and sensitizes lung cancer cells to erlotinib via transcriptional regulation of EGFR. - Wikidata - wikimedia - TriplyDB

CUL4A overexpression enhances lung tumor growth and sensitizes lung cancer cells to erlotinib via transcriptional regulation of EGFR.

CUL4A overexpression enhances lung tumor growth and sensitizes lung cancer cells to erlotinib via transcriptional regulation of EGFR.

http://www.wikidata.org/entity/Q34581688

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The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B Integrative analysis of multi-omics data reveals distinct impacts of DDB1-CUL4 associated factors in human lung adenocarcinomas.CUL4A overexpression as an independent adverse prognosticator in intrahepatic cholangiocarcinoma.Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression.Recurrent Amplification at 13q34 Targets at CUL4A, IRS2, and TFDP1 As an Independent Adverse Prognosticator in Intrahepatic Cholangiocarcinoma CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition Cullin3 promotes breast cancer cells metastasis and epithelial-mesenchymal transition by targeting BRMS1 for degradation.Cullin 4A (CUL4A), a direct target of miR-9 and miR-137, promotes gastric cancer proliferation and invasion by regulating the Hippo signaling pathway.Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma.MicroRNA-155-3p promotes hepatocellular carcinoma formation by suppressing FBXW7 expression.Knockdown of cullin 4A inhibits growth and increases chemosensitivity in lung cancer cells Ubiquitin-specific protease 28 is overexpressed in human glioblastomas and contributes to glioma tumorigenicity by regulating MYC expression.CUL4A promotes proliferation and metastasis of colorectal cancer cells by regulating H3K4 trimethylation in epithelial-mesenchymal transition.microRNA-130a is an oncomir suppressing the expression of CRMP4 in gastric cancer.Cul4B is a novel prognostic marker in cholangiocarcinoma.Knockdown of CUL4B inhibits proliferation and promotes apoptosis of colorectal cancer cells through suppressing the Wnt/β-catenin signaling pathway.HOXD9 promotes epithelial-mesenchymal transition and cancer metastasis by ZEB1 regulation in hepatocellular carcinoma.A new layer of degradation mechanism for PR-Set7/Set8 during cell cycle.Knockdown of CUL4A inhibits invasion and induces apoptosis in osteosarcoma cells.Up-regulated WDR5 promotes gastric cancer formation by induced cyclin D1 expression.Overexpression of TRIM25 in Lung Cancer Regulates Tumor Cell Progression.CUL4A expression in pediatric osteosarcoma tissues and its effect on cell growth in osteosarcoma cells.

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P2860

CUL4A overexpression enhances lung tumor growth and sensitizes lung cancer cells to erlotinib via transcriptional regulation of EGFR.

http://www.wikidata.org/entity/Q34581688

description

2014 nî lūn-bûn

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2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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CUL4A overexpression enhances ...... criptional regulation of EGFR.

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Molecular Cancer

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Guangwei Wei

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Hongtu Yuan

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Mingxin Wen

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Pengju Zhang

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Qin Wang

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Yuli Wang

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Yunshan Wang

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Ziming Liu

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P2860

Cancer statistics, 2012

A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.

TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas

CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation

An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage

CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth

CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis

Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis

Social variations in access to hospital care for patients with colorectal, breast, and lung cancer between 1999 and 2006: retrospective analysis of hospital episode statistics

Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes.

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