CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation - Wikidata - wikimedia - TriplyDB

CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation

CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation

http://www.wikidata.org/entity/Q28290857

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CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis The expanding regulatory universe of p53 in gastrointestinal cancer Motif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulation The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications Regulation of Unperturbed DNA Replication by Ubiquitylation Sequential replication-coupled destruction at G1/S ensures genome stability.Examination of the expanding pathways for the regulation of p21 expression and activity.Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity KSP inhibitor SB743921 inhibits growth and induces apoptosis of breast cancer cells by regulating p53, Bcl-2, and DTL The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance.Degradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage.Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.Efficient parvovirus replication requires CRL4Cdt2-targeted depletion of p21 to prevent its inhibitory interaction with PCNA CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation CRL4Cdt2: master coordinator of cell cycle progression and genome stability p21 in cancer: intricate networks and multiple activities DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression.CUL4A contributes to the biology of basal-like breast tumors through modulation of cell growth and antitumor immune response.The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation.14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer.Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells.Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.Lung tumourigenesis in a conditional Cul4A transgenic mouse model.Damaged DNA-binding protein 1 (DDB1) interacts with Cdh1 and modulates the function of APC/CCdh1.PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.Cullins and cancer.Cables1 controls p21/Cip1 protein stability by antagonizing proteasome subunit alpha type 3.Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia.CUL4A overexpression enhances lung tumor growth and sensitizes lung cancer cells to erlotinib via transcriptional regulation of EGFR.

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CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation

http://www.wikidata.org/entity/Q28290857

description

2008 nî lūn-bûn

@nan

2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2008年の論文

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2008年論文

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2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

CDK inhibitor p21 is degraded ...... phase and after UV irradiation

@ast

CDK inhibitor p21 is degraded ...... phase and after UV irradiation

@en

CDK inhibitor p21 is degraded ...... phase and after UV irradiation

@nl

type

label

CDK inhibitor p21 is degraded ...... phase and after UV irradiation

@ast

CDK inhibitor p21 is degraded ...... phase and after UV irradiation

@en

CDK inhibitor p21 is degraded ...... phase and after UV irradiation

@nl

prefLabel

CDK inhibitor p21 is degraded ...... phase and after UV irradiation

@ast

CDK inhibitor p21 is degraded ...... phase and after UV irradiation

@en

CDK inhibitor p21 is degraded ...... phase and after UV irradiation

@nl

P1433

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P1433

Journal of Biological Chemistry

P1476

CDK inhibitor p21 is degraded ...... phase and after UV irradiation

@en

P2093

Hiroka Iida

http://www.w3.org/2001/XMLSchema#string

Masato Michishita

http://www.w3.org/2001/XMLSchema#string

Toshihiro Takami

http://www.w3.org/2001/XMLSchema#string

Toshiki Tsurimoto

http://www.w3.org/2001/XMLSchema#string

Yasushi Shiomi

http://www.w3.org/2001/XMLSchema#string

P2860

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome

Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint

Preventing re-replication of chromosomal DNA.

DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1

Loss of Geminin induces rereplication in the presence of functional p53

CDK inhibitors: positive and negative regulators of G1-phase progression

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

P304

29045-29052

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scholarly article

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2064825

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P356

10.1074/JBC.M806045200

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P433

43

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P478

283

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Hideo Nishitani

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2008-08-14T00:00:00Z

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18703516

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P921

P932

2662008

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