Inhibition of protein-protein association by small molecules: approaches and progress.
about
SuperMimic--fitting peptide mimetics into protein structures.Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinityStructure of a complex of human lactoferrin N-lobe with pneumococcal surface protein a provides insight into microbial defense mechanismHot-spot analysis to dissect the functional protein-protein interface of a tRNA-modifying enzymeThe SCF ubiquitin ligase: insights into a molecular machineAtomic analysis of protein-protein interfaces with known inhibitors: the 2P2I databaseModulating protein-protein interactions with small molecules: the importance of binding hotspots.Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexesIdentification of hot-spot residues in protein-protein interactions by computational docking.An integrative in silico approach for discovering candidates for drug-targetable protein-protein interactions in interactome dataA systematic method for identifying small-molecule modulators of protein-protein interactions.Identification and mapping of self-assembling protein domains encoded by the Escherichia coli K-12 genome by use of lambda repressor fusions.N-substituted pyrrole derivatives as novel human immunodeficiency virus type 1 entry inhibitors that interfere with the gp41 six-helix bundle formation and block virus fusion.MS-DOCK: accurate multiple conformation generator and rigid docking protocol for multi-step virtual ligand screening.Identifying small-molecule modulators of protein-protein interactions.The SCHOOL of nature: I. Transmembrane signaling.Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain bindersDesign, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.Assessing the druggability of protein-protein interactions by a supervised machine-learning method.Identification of small molecule inhibitors of Interleukin-18.Botulinum neurotoxin A protease: discovery of natural product exosite inhibitorsDr. PIAS: an integrative system for assessing the druggability of protein-protein interactions.Discovering small-molecule estrogen receptor α/coactivator binding inhibitors: high-throughput screening, ligand development, and models for enhanced potency.Targeting protein-protein interactions for therapeutic intervention: a challenge for the future.Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactionsDual targeting antibacterial peptide inhibitor of early lipid A biosynthesis.Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactionsThe SCHOOL of nature: III. From mechanistic understanding to novel therapiesLearning a peptide-protein binding affinity predictor with kernel ridge regression.Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: identification of pharmacophoric elements.Age related changes in pancreatic beta cells: A putative extra-cerebral site of Alzheimer's pathology.Inhibiting the p53-MDM2 interaction: an important target for cancer therapy.Searching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach.Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?Crystallization of interleukin-18 for structure-based inhibitor design.Inhibition of β-catenin signaling suppresses pancreatic tumor growth by disrupting nuclear β-catenin/TCF-1 complex: critical role of STAT-3.Virstatin inhibits dimerization of the transcriptional activator ToxTCross talk between NADPH oxidase and autophagy in pulmonary artery endothelial cells with intrauterine persistent pulmonary hypertensionTargeting the p53-MDM2 interaction to treat cancer.
P2860
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P2860
Inhibition of protein-protein association by small molecules: approaches and progress.
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Inhibition of protein-protein association by small molecules: approaches and progress.
@ast
Inhibition of protein-protein association by small molecules: approaches and progress.
@en
Inhibition of protein-protein association by small molecules: approaches and progress.
@nl
type
label
Inhibition of protein-protein association by small molecules: approaches and progress.
@ast
Inhibition of protein-protein association by small molecules: approaches and progress.
@en
Inhibition of protein-protein association by small molecules: approaches and progress.
@nl
prefLabel
Inhibition of protein-protein association by small molecules: approaches and progress.
@ast
Inhibition of protein-protein association by small molecules: approaches and progress.
@en
Inhibition of protein-protein association by small molecules: approaches and progress.
@nl
P356
P1476
Inhibition of protein-protein association by small molecules: approaches and progress.
@en
P2093
Peter L Toogood
P304
P356
10.1021/JM010468S
P407
P577
2002-04-01T00:00:00Z