Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.
about
The cellular phenotype of Roberts syndrome fibroblasts as revealed by ectopic expression of ESCO2ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repairEnhancement of RAD51 recombinase activity by the tumor suppressor PALB2.FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathwayMRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaksFanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repairFANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repairStructural basis for recruitment of BRCA2 by PALB2PALB2 is an integral component of the BRCA complex required for homologous recombination repairPALB2 regulates recombinational repair through chromatin association and oligomerizationBreast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forksBreast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistanceHomologous recombination in DNA repair and DNA damage toleranceMolecular pathogenesis and clinical management of Fanconi anemiaMutations of the SLX4 gene in Fanconi anemiaSusceptibility pathways in Fanconi's anemia and breast cancerHow the fanconi anemia pathway guards the genomeAnalysis of PALB2/FANCN-associated breast cancer familiesIdentification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repairInterplay between Fanconi anemia and homologous recombination pathways in genome integrityDiseases associated with defective responses to DNA damageFanconi anemia and the cell cycle: new perspectives on aneuploidyStructure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage responseHomologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteinsA Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous RecombinationA novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51PALB2: the hub of a network of tumor suppressors involved in DNA damage responsesFANCI protein binds to DNA and interacts with FANCD2 to recognize branched structuresMitotic homologous recombination maintains genomic stability and suppresses tumorigenesisFanconi anaemia and the repair of Watson and Crick DNA crosslinksHES1 is a novel interactor of the Fanconi anemia core complexCooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombinationMinding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forksLoss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppressionPalb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancerBRCA2 is required for neurogenesis and suppression of medulloblastomaNovel germline PALB2 truncating mutations in African American breast cancer patientsExpanded roles of the Fanconi anemia pathway in preserving genomic stability
P2860
Q21142763-89D164A5-96B8-48D3-B113-4DB0D2F5FFF2Q24300467-3314B050-E542-4C18-A237-0E9ADBFDE8F0Q24301052-C8267449-17B5-48DA-9FAF-D658F556D651Q24301340-54CB9D99-98F2-4B18-9C86-1DE0178C06E2Q24304427-3FBE1505-4107-4D53-9249-952A226C9A63Q24306790-EFFB33A1-7CD1-42AD-B66C-159649A4B246Q24307531-0FDA03D0-D795-4D6A-81CC-F1F1241BE663Q24315682-B7E52166-EF98-4903-AF35-EDF52C51F6AFQ24315745-DC6A62B2-492F-4004-AACE-685C305BC502Q24316113-DB41CE59-6F94-4BFB-8E27-54ABA6C19EC3Q24322952-EF7AC25B-58D7-4D98-9C04-6FCEEA9364D1Q24328790-C3E0BFF3-1EFE-4B8A-AA0F-CD6E087AC4A3Q24338777-104DA445-8264-493B-8B9B-D7E3F8C5D05DQ24599364-3C3AA71B-D9E6-4F1A-8479-B8FD162BE2B4Q24601150-08F0AA4C-EBFD-4F01-A898-563356C1EC30Q24621696-F1F9834E-C21B-4AD8-B402-A995C2894FF4Q24628650-1DEF531B-FEE9-41C5-AEBA-9F85AB554717Q24628760-140DDEFF-4B0C-4375-B67F-611FA803E054Q24634556-4B77A808-F657-422E-9939-211881D1BD2BQ24683771-C7ED7B6F-3816-4ED6-A541-714AC1694D33Q24685928-2D708AB5-2844-494A-9B15-7A89AB2CD90BQ26753126-8B4B6B4D-35BC-4F04-A79F-B9C838A1613EQ26997852-83BE30B6-F5E6-4E9E-8BD9-6FC226B2729DQ27014905-86485AD1-879F-4EC1-A7C6-2EEF67038E3BQ27679861-35F2AA5B-2E52-4A53-B7A8-E38114034945Q28085364-AA8A4279-9F85-4B19-8FC5-6EF24243EE7BQ28115483-8DA1D3BD-DB6C-4B60-BCE1-E346E85D0E2DQ28119199-B99D4018-5558-4A01-A7F2-8AA11D09FEF1Q28243398-140C31D6-61C1-4A4B-81F1-BCB288F3603FQ28250124-22B68CB1-27F4-4228-BDE1-1842E37EAE73Q28274000-4FE866A8-2FDF-4F3C-8C86-420029B04AEAQ28283549-6F669250-240A-43AA-94A0-FB09777441F4Q28283737-5969F35F-3FE7-4AEB-8AD0-C3969B28EFE1Q28294199-286742C9-67F8-42AC-B954-074975287C5EQ28294399-EB97A25E-4230-42AA-BB2D-2CF5FA2587E7Q28512158-9FB4AB2A-28FC-4571-82EC-ECED7E9F0290Q28586302-816F3C53-D041-47D7-98FE-29D2585B4E87Q28590758-3A159705-58ED-41F4-AF77-6E6D39B39DC6Q28741002-1BAB3F6D-22BC-491B-B18F-78050D98A60FQ28749668-F9B14CF3-3E9D-4753-B5CC-098C4C38DA4F
P2860
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.
@ast
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.
@en
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.
@nl
type
label
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.
@ast
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.
@en
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.
@nl
prefLabel
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.
@ast
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.
@en
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.
@nl
P2093
P356
P1433
P1476
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.
@en
P2093
Abdellatif Errami
David M Livingston
Hans Joenje
Johan P de Winter
Josephine C Dorsman
Julian Llera
Martin A Rooimans
Najim Ameziane
Qing Sheng
P2888
P304
P356
10.1038/NG1942
P407
P577
2006-12-31T00:00:00Z