Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. - Wikidata - wikimedia - TriplyDB

Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis.

Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis.

http://www.wikidata.org/entity/Q34600313

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Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3.Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis p38 mitogen-activated protein kinase controls NF-kappaB transcriptional activation and tumor necrosis factor alpha production through RelA phosphorylation mediated by mitogen- and stress-activated protein kinase 1 in response to Borrelia burgdorferi Cellular targeting in autoimmunity Dual Inhibition of Rip2 and IRAK1/4 Regulates IL-1β and IL-6 in Sarcoidosis Alveolar Macrophages and Peripheral Blood Mononuclear Cells Differential roles of MAPK kinases MKK3 and MKK6 in osteoclastogenesis and bone loss.MKK3, an upstream activator of p38, contributes to formalin phase 2 and late allodynia in mice Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6.Dysregulation of p38 and MKP-1 in response to NOD1/TLR4 stimulation in sarcoid bronchoalveolar cells.Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium.Optical tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and non-DMARD efficacy in collagen antibody-induced arthritis Inhibitory effects of intrathecal p38β antisense oligonucleotide on bone cancer pain in rats Antileishmanial effect of 18β-glycyrrhetinic acid is mediated by Toll-like receptor-dependent canonical and noncanonical p38 activation Decreased collagen-induced arthritis severity and adaptive immunity in MKK-6-deficient mice.Attachment to laminin-111 facilitates transforming growth factor beta-induced expression of matrix metalloproteinase-3 in synovial fibroblasts.Survivin is an essential mediator of arthritis interacting with urokinase signalling.Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6 cPLA(2)α gene activation by IL-1β is dependent on an upstream kinase pathway, enzymatic activation and downstream 15-lipoxygenase activity: a positive feedback loop Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade.Mitogen activated protein kinase inhibitors: where are we now and where are we going?Late-breaking news from the "4th International Meeting on Inflammatory Bowel Diseases" Capri, 2006.Acid-sensing ion channel 3 deficiency increases inflammation but decreases pain behavior in murine arthritis.Developments in the synovial biology field 2006.The role of the innate immune system in granulomatous disorders.p38 pathway kinases as anti-inflammatory drug targets.p38 MAPK signaling in oral-related diseases.The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis Metalloproteases as potential therapeutic targets in arthritis treatment.Role of MAPK kinase 6 in arthritis: distinct mechanism of action in inflammation and cytokine expression.Recent advances in neutralizing the IL-6 pathway in arthritis.Garden of therapeutic delights: new targets in rheumatic diseases p38(MAPK): stress responses from molecular mechanisms to therapeutics."Go upstream, young man": lessons learned from the p38 saga.The p38 MAPK Pathway in Rheumatoid Arthritis: A Sideways Look.Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors.Mechanisms of the joint-protective effects of p38 MAPK inhibitors in rodent arthritis.Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer.MKK3 mediates inflammatory response through modulation of mitochondrial function Inhibitors of MAPK pathway ERK1/2 or p38 prevent the IL-1{beta}-induced up-regulation of SRP72 autoantigen in Jurkat cells.MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model.

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Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis.

http://www.wikidata.org/entity/Q34600313

description

2006 nî lūn-bûn

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2006 թվականի մարտին հրատարակված գիտական հոդված

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2006年の論文

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年學術文章

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name

Mitogen-activated protein kina ...... ion in inflammatory arthritis.

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Mitogen-activated protein kina ...... ion in inflammatory arthritis.

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Mitogen-activated protein kina ...... ion in inflammatory arthritis.

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Mitogen-activated protein kina ...... ion in inflammatory arthritis.

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Mitogen-activated protein kina ...... ion in inflammatory arthritis.

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Mitogen-activated protein kina ...... ion in inflammatory arthritis.

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Mitogen-activated protein kina ...... ion in inflammatory arthritis.

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Mitogen-activated protein kina ...... ion in inflammatory arthritis.

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Proceedings of the National Academy of Sciences of the United States of America

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Mitogen-activated protein kina ...... ion in inflammatory arthritis.

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David L Boyle

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Deepa Hammaker

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Gary S Firestein

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Maripat Corr

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Richard A Flavell

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Roger J Davis

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Tomoyuki Inoue

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P2860

A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3

Characterization of the structure and function of a novel MAP kinase kinase (MKK6)

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

Quantitative biomarker analysis of synovial gene expression by real-time PCR

Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression

MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels

Evolving concepts of rheumatoid arthritis

Variation in IL-1beta gene expression is a major determinant of genetic differences in arthritis aggressivity in mice

Expression and activation of mitogen-activated protein kinase kinases-3 and -6 in rheumatoid arthritis

Inhibitors of p38 mitogen-activated protein kinase for the treatment of rheumatoid arthritis.

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103

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