Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo - Wikidata - wikimedia - TriplyDB

Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo

Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo

http://www.wikidata.org/entity/Q34606336

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Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells Proto-oncogene PBF/PTTG1IP regulates thyroid cell growth and represses radioiodide treatment RLIP76 regulates PI3K/Akt signaling and chemo-radiotherapy resistance in pancreatic cancer Protein kinase A and B-Raf mediate extracellular signal-regulated kinase activation by thyrotropin cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.Update: the status of clinical trials with kinase inhibitors in thyroid cancer The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors.Lessons from mouse models of thyroid cancer.Anaplastic Thyroid Carcinoma: Current Treatments and Potential New Therapeutic Options with Emphasis on TfR1/CD71.NRAS codon 61 mutation is associated with distant metastasis in patients with follicular thyroid carcinoma.RAS Interaction with PI3K: More Than Just Another Effector Pathway Evaluation of PTEN, PI3K, MTOR, and KRAS expression and their clinical and prognostic relevance to differentiated thyroid carcinoma Cross-talk between PI3K and estrogen in the mouse thyroid predisposes to the development of follicular carcinomas with a higher incidence in females.Molecular pathogenesis and mechanisms of thyroid cancer Synergistic signaling of KRAS and thyroid hormone receptor β mutants promotes undifferentiated thyroid cancer through MYC up-regulation.Feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1 are involved in arsenite-induced cell malignant transformation Inhibition of AMPK and Krebs cycle gene expression drives metabolic remodeling of Pten-deficient preneoplastic thyroid cells.Mutationally activated BRAF(V600E) elicits papillary thyroid cancer in the adult mouse Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo.Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis.Modulation of sodium iodide symporter in thyroid cancer Medullary and papillary carcinoma of the thyroid gland occurring as a collision tumor with lymph node metastasis: A case report.Modeling follicular thyroid cancer for future therapies Clinical utility of RAS mutations in thyroid cancer: a blurred picture now emerging clearer.Orthotopic mouse models for the preclinical and translational study of targeted therapies against metastatic human thyroid carcinoma with BRAF(V600E) or wild-type BRAF Mouse models of follicular and papillary thyroid cancer progression.Association between the KRAS Gene Polymorphisms and Papillary Thyroid Carcinoma in a Chinese Han Population.Reciprocal positive regulation between Cx26 and PI3K/Akt pathway confers acquired gefitinib resistance in NSCLC cells via GJIC-independent induction of EMT.Mouse models of thyroid cancer: A 2015 update.FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma Evolving approaches to patients with advanced differentiated thyroid cancer Thyroid-specific ablation of the Carney complex gene, PRKAR1A, results in hyperthyroidism and follicular thyroid cancer.Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss.Molecular differences between human thyroid follicular adenoma and carcinoma revealed by analysis of a murine model of thyroid cancer.The PLK1 inhibitor GSK461364A is effective in poorly differentiated and anaplastic thyroid carcinoma cells, independent of the nature of their driver mutations Clinicopathological and molecular histochemical review of skull base metastasis from differentiated thyroid carcinoma Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis Immune Suppression Mediated by Myeloid and Lymphoid Derived Immune Cells in the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by HrasG12V and Pten Loss.Genetic alterations in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancer.Thyroid cancer in 2010: a roadmap for targeted therapies.

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P2860

Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo

http://www.wikidata.org/entity/Q34606336

description

2009 nî lūn-bûn

@nan

2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի ապրիլին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Oncogenic Kras requires simult ...... yroid epithelial cells in vivo

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Oncogenic Kras requires simult ...... yroid epithelial cells in vivo

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Oncogenic Kras requires simult ...... yroid epithelial cells in vivo

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Oncogenic Kras requires simult ...... yroid epithelial cells in vivo

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Oncogenic Kras requires simult ...... yroid epithelial cells in vivo

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Oncogenic Kras requires simult ...... yroid epithelial cells in vivo

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Oncogenic Kras requires simult ...... yroid epithelial cells in vivo

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0008-5472.CAN-09-0024

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Cancer Research

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Oncogenic Kras requires simult ...... yroid epithelial cells in vivo

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P2093

Antonio Di Cristofano

http://www.w3.org/2001/XMLSchema#string

Kelly A Miller

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Kristen Baker

http://www.w3.org/2001/XMLSchema#string

Nicole Yeager

http://www.w3.org/2001/XMLSchema#string

Samuel Refetoff

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Xiao-Hui Liao

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P2860

Pten dose dictates cancer progression in the prostate

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

Activation of AKT kinases in cancer: implications for therapeutic targeting.

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.

Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases.

Expression of p21cip1, p27kip1, and p16INk4a cyclin-dependent kinase inhibitors in papillary thyroid carcinoma: correlation with clinicopathological factors.

A conditional feedback loop regulates Ras activity through EphA2.

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

Improved radioimmunoassay for measurement of mouse thyrotropin in serum: strain differences in thyrotropin concentration and thyrotroph sensitivity to thyroid hormone.

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3689-3694

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scholarly article

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10.1158/0008-5472.CAN-09-0024

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8

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69

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2009-04-07T00:00:00Z

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19351816

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2669852

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