A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins. - Wikidata - wikimedia - TriplyDB

A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins.

A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins.

http://www.wikidata.org/entity/Q34609728

about

Identification of PP2A complexes and pathways involved in cell transformation The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity CRL4-DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation.Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer.Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1.Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells.CIP2A is overexpressed in non-small cell lung cancer and correlates with poor prognosis.A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening.Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.Kinetic analysis of BCL11B multisite phosphorylation-dephosphorylation and coupled sumoylation in primary thymocytes by multiple reaction monitoring mass spectroscopy.Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice.SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS.Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways.Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer.Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity Evaluation of 9-cis retinoic acid and mitotane as antitumoral agents in an adrenocortical xenograft model.Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin Regulation of transcription factor activity by interconnected post-translational modifications.Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.Clinical significance of cancerous inhibitor of protein phosphatase 2A in human cancers.The Interplay between PP2A and microRNAs in Leukemia.Inhibition of protein methylesterase 1 decreased cancerous phenotypes in endometrial adenocarcinoma cell lines and xenograft tumor models.Characterization of SET/I2PP2A isoforms in dogs.Targeting inhibitor 2 of protein phosphatase 2A as a therapeutic strategy for prostate cancer treatment.Inter-cellular adhesion disruption and the RAS/RAF and beta-catenin signalling in lung cancer progression.The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism.PPP2R1A mutations are common in the serous type of endometrial cancer.Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression.Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer.The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model.PP2A as the Main Node of Therapeutic Strategies and Resistance Reversal in Triple-Negative Breast Cancer.Phosphoproteomics Profiling of Nonsmall Cell Lung Cancer Cells Treated with a Novel Phosphatase Activator.Protein Phosphatase 2A in the Regulation of Wnt Signaling, Stem Cells, and Cancer.Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression.

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A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins.

http://www.wikidata.org/entity/Q34609728

description

2008 nî lūn-bûn

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2008 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2008 թվականի հունիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

A tumor suppressor role for PP ...... yc and other key oncoproteins.

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A tumor suppressor role for PP ...... yc and other key oncoproteins.

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A tumor suppressor role for PP ...... yc and other key oncoproteins.

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type

label

A tumor suppressor role for PP ...... yc and other key oncoproteins.

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A tumor suppressor role for PP ...... yc and other key oncoproteins.

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A tumor suppressor role for PP ...... yc and other key oncoproteins.

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A tumor suppressor role for PP ...... yc and other key oncoproteins.

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A tumor suppressor role for PP ...... yc and other key oncoproteins.

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A tumor suppressor role for PP ...... yc and other key oncoproteins.

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Cancer and Metastasis Reviews

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A tumor suppressor role for PP ...... yc and other key oncoproteins.

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Hugh K Arnold

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Rosalie C Sears

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P2860

PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells

Absence of PPP2R1A mutations in Wilms tumor

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55

Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit

Identification of c-MYC as a target of the APC pathway

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.

The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo

Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

Structure of the protein phosphatase 2A holoenzyme

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