Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally
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Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factorsbic, a novel gene activated by proviral insertions in avian leukosis virus-induced lymphomas, is likely to function through its noncoding RNAInsertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomasTargeting the Pim kinases in multiple myelomaA role for E2F activities in determining the fate of Myc-induced lymphomagenesisAssociation of Nuclear PIM1 Expression with Lymph Node Metastasis and Poor Prognosis in Patients with Lung Adenocarcinoma and Squamous Cell CarcinomaPAP-1, a novel target protein of phosphorylation by pim-1 kinaseIdentification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleusPIM1 kinase as a target for cancer therapyThe serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitorTransgenic models of lymphoid neoplasia and development of a pan-hematopoietic vectorPIM-1 kinase expression in adipocytic neoplasms: diagnostic and biological implications.Genetic Modeling of PIM Proteins in Cancer: Proviral Tagging and Cooperation with Oncogenes, Tumor Suppressor Genes, and Carcinogens.Oncogene activation in myeloid leukemias by Graffi murine leukemia virus proviral integrationReassessing the role of C-MYB in tumorigenesis.Core-binding factor influences the disease specificity of Moloney murine leukemia virusPathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression.A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.Transcriptional amplification in tumor cells with elevated c-Myc.Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance.Avian bic, a gene isolated from a common retroviral site in avian leukosis virus-induced lymphomas that encodes a noncoding RNA, cooperates with c-myc in lymphomagenesis and erythroleukemogenesisBmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis.Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma.Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells.In vivo analysis of Pim-1 deficiencyCharacterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice.Retroviral insertional mutagenesis identifies oncogene cooperation.Differential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases.PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice.Tumorigenesis in transgenic mice: identification and characterization of synergizing oncogenes.The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells.Molecular pathways in follicular lymphoma.Expression of a Pim-1 transgene accelerates lymphoproliferation and inhibits apoptosis in lpr/lpr mice.MoMuLV proviral integrations identified by Sup-F selection in tumors from infected myc/pim bitransgenic mice correlate with activation of the gfi-1 gene.Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice.Identification of quinones as novel PIM1 kinase inhibitorsPIM kinases as therapeutic targets against advanced melanoma.Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2.
P2860
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P2860
Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally
description
1991 nî lūn-bûn
@nan
1991 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
@zh-cn
1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
@yue
name
Mice bearing the E mu-myc and ...... pre-B-cell leukemia prenatally
@ast
Mice bearing the E mu-myc and ...... pre-B-cell leukemia prenatally
@en
Mice bearing the E mu-myc and ...... pre-B-cell leukemia prenatally
@nl
type
label
Mice bearing the E mu-myc and ...... pre-B-cell leukemia prenatally
@ast
Mice bearing the E mu-myc and ...... pre-B-cell leukemia prenatally
@en
Mice bearing the E mu-myc and ...... pre-B-cell leukemia prenatally
@nl
prefLabel
Mice bearing the E mu-myc and ...... pre-B-cell leukemia prenatally
@ast
Mice bearing the E mu-myc and ...... pre-B-cell leukemia prenatally
@en
Mice bearing the E mu-myc and ...... pre-B-cell leukemia prenatally
@nl
P2093
P2860
P356
P1476
Mice bearing the E mu-myc and ...... pre-B-cell leukemia prenatally
@en
P2093
P2860
P304
P356
10.1128/MCB.11.2.1176
P407
P577
1991-02-01T00:00:00Z