Predicting evolutionary potential: in vitro evolution accurately reproduces natural evolution of the tem beta-lactamase.
about
Quantifying the adaptive potential of an antibiotic resistance enzymeThe genetic code constrains yet facilitates Darwinian evolutionRAISE: a simple and novel method of generating random insertion and deletion mutationsEscherichia coli β-Lactamases: What Really MattersGenetic and Structural Characterization of an L201P Global Suppressor Substitution in TEM-1 β-LactamaseDirected evolution of Mycobacterium tuberculosis β-lactamase reveals gatekeeper residue that regulates antibiotic resistance and catalytic efficiencyBridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59Environmental changes bridge evolutionary valleysNetwork models of TEM β-lactamase mutations coevolving under antibiotic selection show modular structure and anticipate evolutionary trajectoriesParallel genotypic adaptation: when evolution repeats itselfDiversity and evolution of the class A chromosomal beta-lactamase gene in Klebsiella pneumoniae.GeneHunter, a transposon tool for identification and isolation of cryptic antibiotic resistance genesIn vitro evolution predicts that the IMP-1 metallo-beta-lactamase does not have the potential to evolve increased activity against imipenem.Mistranslation can enhance fitness through purging of deleterious mutations.Enzymatic analysis of the effect of naturally occurring Leu138Pro mutation identified in SHV β-lactamase on hydrolysis of penicillin and ampicillin.Initial mutations direct alternative pathways of protein evolutionExperimental prediction of the evolution of ceftazidime resistance in the CTX-M-2 extended-spectrum beta-lactamaseUnexpected enzyme TEM-126: role of mutation Asp179GluPredicting evolution by in vitro evolution requires determining evolutionary pathways.Clinically relevant Gram-negative resistance mechanisms have no effect on the efficacy of MC-1, a novel siderophore-conjugated monocarbam.Designing antibiotic cycling strategies by determining and understanding local adaptive landscapes.Experimental prediction of the natural evolution of antibiotic resistanceExperimental prediction of the evolution of cefepime resistance from the CMY-2 AmpC beta-lactamase.Directed evolution of aminoglycoside phosphotransferase (3') type IIIa variants that inactivate amikacin but impose significant fitness costs.Role of pleiotropy during adaptation of TEM-1 β-lactamase to two novel antibiotics.Rational design of antibiotic treatment plans: a treatment strategy for managing evolution and reversing resistance.Origin and evolution of antibiotic resistance: the common mechanisms of emergence and spread in water bodies.Systematic Mapping of Protein Mutational Space by Prolonged Drift Reveals the Deleterious Effects of Seemingly Neutral MutationsAntibiotics as selectors and accelerators of diversity in the mechanisms of resistance: from the resistome to genetic plasticity in the β-lactamases worldHigh rate of mobilization for blaCTX-Ms.High frequency of hotspot mutations in core genes of Escherichia coli due to short-term positive selection.Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance.Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance.Haemophilus influenzae bla(ROB-1) mutations in hypermutagenic deltaampC Escherichia coli conferring resistance to cefotaxime and beta-lactamase inhibitors and increased susceptibility to cefaclorPatterns of Epistasis between beneficial mutations in an antibiotic resistance gene.How mutational epistasis impairs predictability in protein evolution and designRecombination and selection can remove blaTEM alleles from bacterial populations.R164H and V240H replacements by site-directed mutagenesis of TEM-149 extended-spectrum β-lactamase: kinetic analysis of TEM-149H240 and TEM-149H164-H240 laboratory mutants.Adaptive benefits from small mutation supplies in an antibiotic resistance enzyme.Environmental pleiotropy and demographic history direct adaptation under antibiotic selection
P2860
Q21563371-395DDC4A-52A8-46D3-9ADF-E86B7B34B3D7Q24629982-AF6F018C-DE89-4F92-A6A1-22D86E2FB29EQ25256082-4B54E607-8104-486B-9181-72700C33B2EFQ26749590-471E2473-E436-4F56-B5DB-8B824600B581Q27652316-5E07FDF6-7CA0-4CFD-ACAB-D3BBCB843785Q27679915-EF49EA04-FEFD-48CA-BAF2-0A4934952BFFQ27681091-B93EFB0B-2684-41C5-9CA5-1B3F9D9EE5BFQ28272911-ECE028E8-C68D-4F72-B716-6663C9C36975Q28477196-AFC9C3DC-F764-4AF0-BCAE-F6EE7780114DQ28757842-AD576C2F-CD1F-40C1-9CF2-497AC0CEF95EQ30939927-4CFF3ABA-4E58-4DB3-9EDC-66605FB5D030Q31028546-8FCC9F06-FE83-4428-9AC4-007529E412C7Q33198614-0B6955C1-70B9-409E-9D91-4CA54AC9735BQ33754318-1B7A5CD5-5FD5-4588-A448-C64DC062820AQ33811386-F34E19E1-F8ED-40A3-90E3-EA7E693A9C0CQ33847781-2BEA85A7-2978-4817-B66C-1E647CECA04AQ33857639-4738A5E0-C02E-4CDE-A5C6-E22AB2F13D39Q34077105-370329F8-2610-4FFC-9E43-5E14B5CED70AQ34112966-F5C0F27D-9984-4CB6-B3E4-D7898C77EE87Q34425933-427AFFDF-264B-4427-BECD-057369B3AEF0Q34589777-534643ED-2D64-4FD3-A82C-5DEB2D77A5A9Q34617402-9553D406-3AFD-4B9A-8535-B5E4391FA5B5Q34617581-8BE525DB-ED74-4ECC-A1A5-3CB6FFC18F52Q35034759-CA7A9812-2A41-4D37-A3AE-26DA424EC605Q35236711-49100ED4-4520-44F2-A35B-13C21587369DQ35623227-FD57901C-E890-49E5-85C4-E02C517172A8Q35698156-0CF3FC9F-2138-410D-94A4-AC624BAC6843Q35746027-13FB1F1B-1D4E-4F71-8C2D-213B96103304Q36595848-804CEA5C-E614-4E61-84DE-DFA152D5AD07Q36944691-8BAFD3D1-E7A3-45B1-89CF-6FE5C3AE16A1Q37282428-39FB20CA-EB18-491B-BC51-201483AB9477Q38367666-742BAB2A-1542-4154-97FE-AAC4013BAFF7Q39686774-C391DF9E-F715-475B-BBCB-CC589C196DB5Q39792503-E817E8B3-DD2F-4EBE-A97C-F12D49F33E32Q41864870-560EECE6-1C2E-4FD1-93B6-6E680C30C10AQ42197694-633817B3-A928-4F0D-8F5E-EE6359559383Q42444329-49E61749-B66B-4579-9DED-657451B35A00Q42953196-1EF463B3-8303-4B54-BF97-FAB821BB77CDQ50043213-090C3B21-231A-4D19-B8E3-CABE4AB8E3B3Q58997135-7F0A241F-56E6-40D3-91F0-4DBEDEE144E9
P2860
Predicting evolutionary potential: in vitro evolution accurately reproduces natural evolution of the tem beta-lactamase.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Predicting evolutionary potent ...... ion of the tem beta-lactamase.
@ast
Predicting evolutionary potent ...... ion of the tem beta-lactamase.
@en
Predicting evolutionary potent ...... ion of the tem beta-lactamase.
@nl
type
label
Predicting evolutionary potent ...... ion of the tem beta-lactamase.
@ast
Predicting evolutionary potent ...... ion of the tem beta-lactamase.
@en
Predicting evolutionary potent ...... ion of the tem beta-lactamase.
@nl
prefLabel
Predicting evolutionary potent ...... ion of the tem beta-lactamase.
@ast
Predicting evolutionary potent ...... ion of the tem beta-lactamase.
@en
Predicting evolutionary potent ...... ion of the tem beta-lactamase.
@nl
P2860
P1433
P1476
Predicting evolutionary potent ...... ion of the tem beta-lactamase.
@en
P2093
Barry G Hall
Miriam Barlow
P2860
P304
P407
P577
2002-03-01T00:00:00Z