Conversion of isoaspartyl peptides to normal peptides: implications for the cellular repair of damaged proteins.
about
Crystal structure of human L-isoaspartyl-O-methyl-transferase with S-adenosyl homocysteine at 1.6-A resolution and modeling of an isoaspartyl-containing peptide at the active siteA new gene involved in stationary-phase survival located at 59 minutes on the Escherichia coli chromosomeStructural Investigation of a Phosphorylation-Catalyzed, Isoaspartate-Free, Protein Succinimide: Crystallographic Structure of Post-Succinimide His15Asp Histidine-Containing Protein † ‡Complex interactions of the protein L-isoaspartyl methyltransferase and calmodulin revealed with the yeast two-hybrid systemPost-translational modifications modulate ligand recognition by the third PDZ domain of the MAGUK protein PSD-95Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed ratsNonenzymatic deamidation of asparaginyl and glutaminyl residues in proteins.Integrated proteomic analysis of major isoaspartyl-containing proteins in the urine of wild type and protein L-isoaspartate O-methyltransferase-deficient mice.Analysis of isoaspartate in peptides by electrospray tandem mass spectrometry.Proteomic identification of novel substrates of a protein isoaspartyl methyltransferase repair enzyme.The L-isoaspartyl protein repair methyltransferase enhances survival of aging Escherichia coli subjected to secondary environmental stresses.Non-repair pathways for minimizing protein isoaspartyl damage in the yeast Saccharomyces cerevisiae.Isoaspartyl formation in creatine kinase B is associated with loss of enzymatic activity; implications for the linkage of isoaspartate accumulation and neurological dysfunction in the PIMT knockout mouse.Racemization of two proteins over our lifespan: deamidation of asparagine 76 in γS crystallin is greater in cataract than in normal lenses across the age range.Considerations in the identification of endogenous substrates for protein L-isoaspartyl methyltransferase: the case of synuclein.Molecular ageing of alpha- and Beta-synucleins: protein damage and repair mechanisms.Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent.Accelerated protein damage in brains of PIMT+/- mice; a possible model for the variability of cognitive decline in human agingIsoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury.Enzymatic methyl esterification of erythrocyte membrane proteins is impaired in chronic renal failure. Evidence for high levels of the natural inhibitor S-adenosylhomocysteine.A gene at 59 minutes on the Escherichia coli chromosome encodes a lipoprotein with unusual amino acid repeat sequences.Distribution of an L-isoaspartyl protein methyltransferase in eubacteriaDeficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice.In vitro aging of calmodulin generates isoaspartate at multiple Asn-Gly and Asp-Gly sites in calcium-binding domains II, III, and IVThe D-isoAsp-25 variant of histone H2B is highly enriched in active chromatin: potential role in the regulation of gene expression?A protein methyltransferase specific for altered aspartyl residues is important in Escherichia coli stationary-phase survival and heat-shock resistance.Isoaspartyl protein damage and repair in mouse retina.Isoaspartate in ribosomal protein S11 of Escherichia coli.Rice PROTEIN l-ISOASPARTYL METHYLTRANSFERASE isoforms differentially accumulate during seed maturation to restrict deleterious isoAsp and reactive oxygen species accumulation and are implicated in seed vigor and longevity.The microRNA 15a/16-1 cluster down-regulates protein repair isoaspartyl methyltransferase in hepatoma cells: implications for apoptosis regulation.Repair, refold, recycle: how bacteria can deal with spontaneous and environmental damage to proteins.Protein damage and methylation-mediated repair in the erythrocyte.Repair of isoaspartate formation modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain.Phenotypic analysis of seizure-prone mice lacking L-isoaspartate (D-aspartate) O-methyltransferase.Detection and quantitation of succinimide in intact protein via hydrazine trapping and chemical derivatization.The amino terminus of PKA catalytic subunit--a site for introduction of posttranslational heterogeneities by deamidation: D-Asp2 and D-isoAsp2 containing isozymesLimited accumulation of damaged proteins in l-isoaspartyl (D-aspartyl) O-methyltransferase-deficient mice.Structural integrity of histone H2B in vivo requires the activity of protein L-isoaspartate O-methyltransferase, a putative protein repair enzyme.Aberrant synaptic transmission in the hippocampal CA3 region and cognitive deterioration in protein-repair enzyme-deficient mice.Isoaspartate in chrondroitin sulfate proteoglycans of mammalian brain.
P2860
Q24645256-F3858057-99A6-432A-B1A0-F382F45537ADQ24685880-1508980C-72E4-43E0-92CC-2F28459ACDD9Q27651575-0BD99D54-6249-4418-8688-134A1D60D7A7Q28270469-55E6BBD8-742D-4934-8E3E-11361506B7E7Q28540168-FB4D55FA-8B09-4EBF-A3E2-71C72705167EQ28583890-E6DF66F2-3B13-48BA-87C8-31F454C386FFQ30355031-42F54399-D444-4A93-AC5B-8436C91C6C36Q30426046-DCE17ED5-57C9-4E76-9F16-AA57877F65F8Q30647899-033967A7-509A-4914-B1EE-3940AA68CDE2Q33254719-E6A1FCD5-D12C-4733-A16C-1328DF20D7F5Q33730748-822DAEC5-08C4-467E-83B9-88030EA409E1Q33761245-F9689542-8AFF-436F-B7D9-C561D7EA2EDAQ33793594-811AB113-6465-4EE9-9A27-4118490663FAQ34244542-FE7580F0-2FB7-419D-8126-D61657816178Q34384948-3847FA86-7335-4141-989C-A054538B4EACQ34695506-E9E9326B-0360-46AA-9EA4-84FD80EFF221Q35041665-3FAA1403-CEB7-445A-889E-A1F8DCF97420Q35044254-2E1661D7-CA3A-473C-B8BE-103C6E019047Q35163505-1637D053-1B66-4D34-8A4E-560CD41E519EQ35610460-6FB0218D-9896-4F1C-9A9E-4501E3BB2F7BQ36105971-AE9365F8-C47D-40B3-BDD7-818596383261Q36109668-341C6997-8FCE-438E-9482-56F0C1C97EACQ36179871-4D2830E5-2578-4474-865F-6BDF51EA29D3Q36277699-10BA6EE0-0C3A-47B3-B0B4-4A354B92B55AQ36540546-A587680D-9462-40DF-B252-A9B43976ADFAQ37256707-97E8600B-12A3-4BE4-AF83-77593CCAB902Q37637164-BB812439-639D-4014-B5D5-FB9C1F54A4A3Q39495570-044DF248-63FB-4DDD-B148-11C997DF5277Q39912305-DC2DEF0D-6874-495E-B89F-F2C6BDAD2C0BQ39937281-BCF00CF7-D497-49D9-872F-FBABD43AC192Q40369339-FD0C4BF4-7668-4339-8523-FC8DC9C5894BQ40611236-BA831315-04ED-42B1-A318-F1396989BF7DQ41048721-4EAA364A-B08D-488E-9FBB-8DA6F3046C12Q41678289-22346019-4AFC-491C-BBEB-84BC7DAA6AD8Q41833694-18CA41C0-63EE-4FA5-8A8E-BAF9127B8D84Q42567321-A31065F5-E0BE-46DE-8141-7103B281FC43Q43560357-785297CA-4B61-462C-A3ED-ED3E64073697Q43691982-BA5ACED3-45FA-41E0-8614-D308DC78E003Q43840915-056E3429-DDD9-40A5-9578-3B1FA7A1B83AQ44276432-9F46C8BC-20C3-407B-9562-BF085984DD1B
P2860
Conversion of isoaspartyl peptides to normal peptides: implications for the cellular repair of damaged proteins.
description
1987 nî lūn-bûn
@nan
1987 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
name
Conversion of isoaspartyl pept ...... ar repair of damaged proteins.
@ast
Conversion of isoaspartyl pept ...... ar repair of damaged proteins.
@en
Conversion of isoaspartyl pept ...... ar repair of damaged proteins.
@nl
type
label
Conversion of isoaspartyl pept ...... ar repair of damaged proteins.
@ast
Conversion of isoaspartyl pept ...... ar repair of damaged proteins.
@en
Conversion of isoaspartyl pept ...... ar repair of damaged proteins.
@nl
prefLabel
Conversion of isoaspartyl pept ...... ar repair of damaged proteins.
@ast
Conversion of isoaspartyl pept ...... ar repair of damaged proteins.
@en
Conversion of isoaspartyl pept ...... ar repair of damaged proteins.
@nl
P2860
P356
P1476
Conversion of isoaspartyl pept ...... ar repair of damaged proteins.
@en
P2093
P N McFadden
P2860
P304
P356
10.1073/PNAS.84.9.2595
P407
P577
1987-05-01T00:00:00Z