Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3).

Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3).

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http://www.wikidata.org/entity/Q34620898

Q34620898

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Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma The Potential of Vitamin D-Regulated Intracellular Signaling Pathways as Targets for Myeloid Leukemia Therapy Successive phosphorylation of p27(KIP1) protein at serine-10 and C terminus crucially controls its potency to inactivate Cdk2 TPL2 kinase regulates the inflammatory milieu of the myeloma niche Anti-cancer natural products isolated from chinese medicinal herbs 1,25-Dihydroxyvitamin D3 induces monocytic differentiation of human myeloid leukemia cells by regulating C/EBPβ expression through MEF2C ERK5 pathway regulates transcription factors important for monocytic differentiation of human myeloid leukemia cells.The MAPK ERK5, but not ERK1/2, inhibits the progression of monocytic phenotype to the functioning macrophage.Dual role of hematopoietic progenitor kinase 1 (HPK1) as a positive regulator of 1α,25-dihydroxyvitamin D-induced differentiation and cell cycle arrest of AML cells and as a mediator of vitamin D resistance Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-κB activation.CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade.ERK 5/MAPK pathway has a major role in 1α,25-(OH)2 vitamin D3-induced terminal differentiation of myeloid leukemia cells.Role of cell cycle regulatory molecules in retinoic acid- and vitamin D3-induced differentiation of acute myeloid leukaemia cells.Vitamin D Control of Hematopoietic Cell Differentiation and Leukemia.Vitamin D has wide regulatory effects on histone demethylase genes.Activator of G-protein Signaling 3 Controls Renal Epithelial Cell Survival and ERK5 Activation.Established Human Cell Lines as Models to Study Anti-leukemic Effects of Flavonoids.Cell-Type-Specific Effects of Silibinin on Vitamin D-Induced Differentiation of Acute Myeloid Leukemia Cells Are Associated with Differential Modulation of RXRα Levels.TIMELESS Suppresses the Accumulation of Aberrant CDC45·MCM2-7·GINS Replicative Helicase Complexes on Human Chromatin.Enhancement of arabinocytosine (AraC) toxicity to AML cells by a differentiation agent combination.RB in breast cancer: differential effects in estrogen receptor-positive and estrogen receptor-negative disease.Silibinin: an old drug for hematological disorders.Optimal AraC-Cytotoxicity to AML Cells Requires ERK5 Activity.Nuclear ERK5 inhibits progression of leukemic monocytes to macrophages by regulating the transcription factor PU.1 and heat shock protein HSP70.

P2860

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P2860

Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3).

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http://www.wikidata.org/entity/Q34620898

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2010 nî lūn-bûn

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2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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