Druggable protein interaction sites are more predisposed to surface pocket formation than the rest of the protein surface
about
Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatinFast docking on graphics processing units via Ray-CastingStructure-based druggability assessment of the mammalian structural proteome with inclusion of light protein flexibilityEvidence of conformational selection driving the formation of ligand binding sites in protein-protein interfacesSelectivity by small-molecule inhibitors of protein interactions can be driven by protein surface fluctuationsRational design of small-molecule stabilizers of spermine synthase dimer by virtual screening and free energy-based approachUltra-High-Throughput Structure-Based Virtual Screening for Small-Molecule Inhibitors of Protein-Protein Interactions.Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine.Discovery of multiple hidden allosteric sites by combining Markov state models and experimentsDARC 2.0: Improved Docking and Virtual Screening at Protein Interaction SitesState-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.Imbalance in chemical space: How to facilitate the identification of protein-protein interaction inhibitors.Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Screening-based approaches to identify small molecules that inhibit protein-protein interactions.HAPPI-2: a Comprehensive and High-quality Map of Human Annotated and Predicted Protein Interactions.DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites.Choosing the Optimal Rigid Receptor for Docking and Scoring in the CSAR 2013/2014 ExperimentCryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites.Structural properties of non-traditional drug targets present new challenges for virtual screening.Computational solvent mapping in structure-based drug design.Systematic Targeting of Protein-Protein InteractionsComputational functional group mapping for drug discovery.Exploring the structural origins of cryptic sites on proteins.Evolution of In Silico Strategies for Protein-Protein Interaction Drug Discovery
P2860
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P2860
Druggable protein interaction sites are more predisposed to surface pocket formation than the rest of the protein surface
description
2013 nî lūn-bûn
@nan
2013 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մարտին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Druggable protein interaction ...... he rest of the protein surface
@ast
Druggable protein interaction ...... he rest of the protein surface
@en
Druggable protein interaction ...... he rest of the protein surface
@nl
type
label
Druggable protein interaction ...... he rest of the protein surface
@ast
Druggable protein interaction ...... he rest of the protein surface
@en
Druggable protein interaction ...... he rest of the protein surface
@nl
prefLabel
Druggable protein interaction ...... he rest of the protein surface
@ast
Druggable protein interaction ...... he rest of the protein surface
@en
Druggable protein interaction ...... he rest of the protein surface
@nl
P2860
P1476
Druggable protein interaction ...... he rest of the protein surface
@en
P2093
David K Johnson
John Karanicolas
P2860
P304
P356
10.1371/JOURNAL.PCBI.1002951
P577
2013-03-07T00:00:00Z