Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors.
about
Discovery of internalizing antibodies to tumor antigens from phage libraries.Directed evolution of stabilized IgG1-Fc scaffolds by application of strong heat shock to libraries displayed on yeastConstruction of a stability landscape of the CH3 domain of human IgG1 by combining directed evolution with high throughput sequencing.High throughput identification of monoclonal antibodies to membrane bound and secreted proteins using yeast and phage display.Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and functionDesign of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses.Directed evolution of Her2/neu-binding IgG1-Fc for improved stability and resistance to aggregation by using yeast surface display.Chaperone-assisted thermostability engineering of a soluble T cell receptor using phage display.A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor controlPlasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes.T Cell Receptor Engineering and Analysis Using the Yeast Display Platform.Co-evolution of affinity and stability of grafted amyloid-motif domain antibodies.Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex.Directed Evolution of Protein Thermal Stability Using Yeast Surface Display.Design and characterization of a protein superagonist of IL-15 fused with IL-15Rα and a high-affinity T cell receptorAn Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry.Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains.A TCR-based Chimeric Antigen Receptor.Changing the peptide specificity of a human T-cell receptor by directed evolution.Subtle changes at the variable domain interface of the T-cell receptor can strongly increase affinity.
P2860
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P2860
Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors.
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Identification and engineering ...... single-chain T cell receptors.
@ast
Identification and engineering ...... single-chain T cell receptors.
@en
Identification and engineering ...... single-chain T cell receptors.
@nl
type
label
Identification and engineering ...... single-chain T cell receptors.
@ast
Identification and engineering ...... single-chain T cell receptors.
@en
Identification and engineering ...... single-chain T cell receptors.
@nl
prefLabel
Identification and engineering ...... single-chain T cell receptors.
@ast
Identification and engineering ...... single-chain T cell receptors.
@en
Identification and engineering ...... single-chain T cell receptors.
@nl
P2093
P2860
P356
P1476
Identification and engineering ...... single-chain T cell receptors
@en
P2093
Adam S Chervin
Brian M Baker
David M Kranz
Francis K Insaidoo
Kurt H Piepenbrink
P2860
P304
P356
10.1093/PROTEIN/GZQ113
P577
2010-12-14T00:00:00Z