Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway - Wikidata - wikimedia - TriplyDB

Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway

Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway

http://www.wikidata.org/entity/Q34649977

about

T cell receptor signalling in the control of regulatory T cell differentiation and function Control of the thymic medulla and its influence on αβT-cell development Role of Dendritic Cells in the Induction of Lymphocyte Tolerance Influence of maternal immunization with allergens on the thymic maturation of lymphocytes with regulatory potential in children: a broad field for further exploration Targeting the T-cell co-stimulatory CD27/CD70 pathway in cancer immunotherapy: rationale and potential Stimulating CD27 to quantitatively and qualitatively shape adaptive immunity to cancer.Dual function of CD70 in viral infection: modulator of early cytokine responses and activator of adaptive responses.Conserved and divergent aspects of human T-cell development and migration in humanized mice Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells.CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis.Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition.The Role of Dendritic Cells in Central Tolerance mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination Human thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS ligand Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3(+) T Cells mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development.Peripherally induced tregs - role in immune homeostasis and autoimmunity NF-κB signaling mediates homeostatic maturation of new T cells.Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.Regulations of gene expression in medullary thymic epithelial cells required for preventing the onset of autoimmune diseases.Regulatory T cells in atherosclerosis: critical immune regulatory function and therapeutic potential.ATVB Distinguished Scientist Award: How Costimulatory and Coinhibitory Pathways Shape Atherosclerosis.Therapeutic targeting of CD70 and CD27.Development of T-cell tolerance utilizes both cell-autonomous and cooperative presentation of self-antigen.Dendritic cells as gatekeepers of tolerance.CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants.The Importance of Dendritic Cells in Maintaining Immune Tolerance.Immune checkpoint proteins: exploring their therapeutic potential to regulate atherosclerosis.IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes.Host-Derived CD70 Suppresses Murine Graft-versus-Host Disease by Limiting Donor T Cell Expansion and Effector Function.Targeted alpha therapy using a novel CD70 targeted thorium-227 conjugate in in vitro and in vivo models of renal cell carcinoma.Tregs strip dendritic cells of CD70 to regulate Th1 differentiation.The phenotype and activation status of regulatory T cells during Friend retrovirus infection.CCR7 Modulates the Generation of Thymic Regulatory T Cells by Altering the Composition of the Thymic Dendritic Cell Compartment.Trial watch: Dendritic cell-based interventions for cancer therapy.A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla.CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy.T Cell-Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses.CD40 Mediates Maturation of Thymic Dendritic Cells Driven by Self-Reactive CD4+ Thymocytes and Supports Development of Natural Regulatory T Cells.

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P2860

Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway

http://www.wikidata.org/entity/Q34649977

description

2013 nî lūn-bûn

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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2013 թվականի ապրիլին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Epithelial and dendritic cells ...... ment via the CD27-CD70 pathway

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Epithelial and dendritic cells ...... ment via the CD27-CD70 pathway

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Epithelial and dendritic cells ...... ment via the CD27-CD70 pathway

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type

label

Epithelial and dendritic cells ...... ment via the CD27-CD70 pathway

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Epithelial and dendritic cells ...... ment via the CD27-CD70 pathway

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Epithelial and dendritic cells ...... ment via the CD27-CD70 pathway

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prefLabel

Epithelial and dendritic cells ...... ment via the CD27-CD70 pathway

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Epithelial and dendritic cells ...... ment via the CD27-CD70 pathway

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Epithelial and dendritic cells ...... ment via the CD27-CD70 pathway

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Journal of Experimental Medicine

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Epithelial and dendritic cells ...... ment via the CD27-CD70 pathway

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P2093

Daniel J Pennington

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Diogo Fonseca-Pereira

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Gerda van der Horst

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Jannie Borst

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Joana F Neves

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Nikolina Bąbała

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Yanling Xiao

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P2860

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

Control of regulatory T cell development by the transcription factor Foxp3

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Projection of an immunological self shadow within the thymus by the aire protein

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

A function for interleukin 2 in Foxp3-expressing regulatory T cells

Induction of colonic regulatory T cells by indigenous Clostridium species

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715-728

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10.1084/JEM.20112061

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4

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210

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Bruno Silva-Santos

Sabine Middendorp

Jonathan Coquet

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2013-04-01T00:00:00Z

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236098260

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23547099

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3620350

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