Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening.

Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening.

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http://www.wikidata.org/entity/Q34663837

Q34663837

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TAMH: A Useful In Vitro Model for Assessing Hepatotoxic Mechanisms Comparison of in vitro bioactivation of flutamide and its cyano analogue: evidence for reductive activation by human NADPH:cytochrome P450 reductase.Differential regulation of mitogen-activated protein kinase pathways by acetaminophen and its nonhepatotoxic regioisomer 3'-hydroxyacetanilide in TAMH cells.Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models.Identification of the Additional Mitochondrial Liabilities of 2-Hydroxyflutamide When Compared With its Parent Compound, Flutamide in HepG2 Cells.IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR.Toxicogenomic biomarkers for liver toxicity Comparative hepatoprotective effects of tocotrienol analogs against drug-induced liver injury Overcoming Chloroquine Resistance in Malaria: Design, Synthesis, and Structure-Activity Relationships of Novel Hybrid Compounds.Genetical toxicogenomics in Drosophila identifies master-modulatory loci that are regulated by developmental exposure to lead Mitochondrial gene profiling: translational perspectives.Managing the challenge of chemically reactive metabolites in drug development.The primary role of hepatic metabolism in idiosyncratic drug-induced liver injury.Nitroaromatic compounds: Environmental toxicity, carcinogenicity, mutagenicity, therapy and mechanism.Oxidation potentials of N-modified derivatives of the analgesic flupirtine linked to potassium KV 7 channel opening activity but not hepatocyte toxicity.Anticancer potential of 3-(arylideneamino)-2-phenylquinazoline-4(3H)-one derivatives.Sequential and concerted gene expression changes in a chronic in vitro model of parkinsonism.Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice.Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and Its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips.The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p.

P2860

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P2860

Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening.

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http://www.wikidata.org/entity/Q34663837

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2007 nî lūn-bûn

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2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2007年の論文

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2007年論文

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