Effects of helical structures formed by the binding arms of DNAzymes and their substrates on catalytic activity
about
In vitro selection, characterization, and application of deoxyribozymes that cleave RNALocked nucleoside analogues expand the potential of DNAzymes to cleave structured RNA targetsEfficient silencing of gene expression by an ASON-bulge-DNAzyme complex.A novel replicating circular DNAzyme.Rapid preparation of RNA samples for NMR spectroscopy and X-ray crystallography.Exponential growth by cross-catalytic cleavage of deoxyribozymogens.Design of efficient DNAzymes against muscle AChR alpha-subunit cRNA in vitro and in HEK 293 cells.Activity, folding and Z-DNA formation of the 8-17 DNAzyme in the presence of monovalent ions.Nucleic acid mutation analysis using catalytic DNA.Systematic analysis of the role of target site accessibility in the activity of DNA enzymes.Kinetic and thermodynamic characterization of the RNA-cleaving 8-17 deoxyribozyme.RNA cleaving '10-23' DNAzymes with enhanced stability and activity.Structural rearrangements of the 10-23 DNAzyme to beta 3 integrin subunit mRNA induced by cations and their relations to the catalytic activity.Biochemical and Biophysical Understanding of Metal Ion Selectivity of DNAzymes.In vitro selection and characterization of a highly efficient Zn(II)-dependent RNA-cleaving deoxyribozyme.DNAzyme-mediated catalysis with only guanosine and cytidine nucleotides.MNAzymes, a versatile new class of nucleic acid enzymes that can function as biosensors and molecular switches.Inhibition of HIV-1 Integrase gene expression by 10-23 DNAzyme.Design and switch of catalytic activity with the DNAzyme-RNAzyme combination.Probing the effect of minor groove interactions on the catalytic efficiency of DNAzymes 8-17 and 10-23.Mapping of the functional phosphate groups in the catalytic core of deoxyribozyme 10-23.A novel strategy of chemical modification for rate enhancement of 10-23 DNAzyme: a combination of A9 position and 8-aza-7-deaza-2'-deoxyadenosine analogs.
P2860
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P2860
Effects of helical structures formed by the binding arms of DNAzymes and their substrates on catalytic activity
description
1998 nî lūn-bûn
@nan
1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Effects of helical structures ...... bstrates on catalytic activity
@ast
Effects of helical structures ...... bstrates on catalytic activity
@en
Effects of helical structures ...... bstrates on catalytic activity
@nl
type
label
Effects of helical structures ...... bstrates on catalytic activity
@ast
Effects of helical structures ...... bstrates on catalytic activity
@en
Effects of helical structures ...... bstrates on catalytic activity
@nl
prefLabel
Effects of helical structures ...... bstrates on catalytic activity
@ast
Effects of helical structures ...... bstrates on catalytic activity
@en
Effects of helical structures ...... bstrates on catalytic activity
@nl
P2093
P2860
P356
P1476
Effects of helical structures ...... bstrates on catalytic activity
@en
P2093
P2860
P304
P356
10.1093/NAR/26.14.3385
P407
P577
1998-07-01T00:00:00Z