Do ligand binding and solvent exclusion alter the electrostatic character within the oxyanion hole of an enzymatic active site?
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Fundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymesThe Use of Multiscale Molecular Simulations in Understanding a Relationship between the Structure and Function of Biological Systems of the Brain: The Application to Monoamine Oxidase EnzymesSite-specific infrared probes of proteinsTesting Geometrical Discrimination within an Enzyme Active Site: Constrained Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion HoleNitrile Bonds as Infrared Probes of Electrostatics in Ribonuclease SElectrostatic Fields near the Active Site of Human Aldose Reductase: 2. New Inhibitors and Complications Caused by Hydrogen BondsQuantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase.Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active siteAdvances in BioconjugationProtein apparent dielectric constant and its temperature dependence from remote chemical shift effects.Ketosteroid isomerase provides further support for the idea that enzymes work by electrostatic preorganization.Computational Modeling of the Nitrile Stretching Vibration of 5-Cyanoindole in Water.Solvation response along the reaction coordinate in the active site of ketosteroid isomerase.Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase.Direct measurement of the protein response to an electrostatic perturbation that mimics the catalytic cycle in ketosteroid isomeraseSite-Specific Spectroscopic Reporters of the Local Electric Field, Hydration, Structure, and Dynamics of Biomolecules.Using infrared spectroscopy of cyanylated cysteine to map the membrane binding structure and orientation of the hybrid antimicrobial peptide CM15.Combinatorial catalysis employing a visible enzymatic beacon in real time: synthetically versatile (pseudo)halometalation/carbocyclizationsSolvatochromism and the solvation structure of benzophenone.Catalytic efficiency of enzymes: a theoretical analysisMeasuring electric fields and noncovalent interactions using the vibrational stark effect.Calculation of vibrational shifts of nitrile probes in the active site of ketosteroid isomerase upon ligand binding.Impact of mutation on proton transfer reactions in ketosteroid isomerase: insights from molecular dynamics simulationsDecomposition of vibrational shifts of nitriles into electrostatic and hydrogen-bonding effects.Hybrid quantum/classical molecular dynamics simulations of the proton transfer reactions catalyzed by ketosteroid isomerase: analysis of hydrogen bonding, conformational motions, and electrostatics.Integrated and dispersed photon echo studies of nitrile stretching vibration of 4-cyanophenol in methanol.Carbon-deuterium vibrational probes of peptide conformation: alanine dipeptide and glycine dipeptide.Azido-derivatized compounds as IR probes of local electrostatic environment: Theoretical studies.Nitrile and thiocyanate IR probes: molecular dynamics simulation studies.Intrinsic electric fields in ionic liquids determined by vibrational Stark effect spectroscopy and molecular dynamics simulation.Vibrational dynamics and solvatochromism of the label SCN in various solvents and hemoglobin by time dependent IR and 2D-IR spectroscopy.A thiocyanopalladation/carbocyclization transformation identified through enzymatic screening: stereocontrolled tandem C-SCN and C-C bond formation.Nitrile and thiocyanate IR probes: quantum chemistry calculation studies and multivariate least-square fitting analysis.Cyanylated Cysteine Reports Site-Specific Changes at Protein-Protein-Binding Interfaces Without Perturbation.Synthesis of 5-Cyano-Tryptophan as a Two-Dimensional Infrared Spectroscopic Reporter of Structure.Ag/Pyridine Co-Mediated Oxidative Arylthiocyanation of Activated Alkenes
P2860
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P2860
Do ligand binding and solvent exclusion alter the electrostatic character within the oxyanion hole of an enzymatic active site?
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Do ligand binding and solvent ...... e of an enzymatic active site?
@ast
Do ligand binding and solvent ...... e of an enzymatic active site?
@en
Do ligand binding and solvent ...... e of an enzymatic active site?
@nl
type
label
Do ligand binding and solvent ...... e of an enzymatic active site?
@ast
Do ligand binding and solvent ...... e of an enzymatic active site?
@en
Do ligand binding and solvent ...... e of an enzymatic active site?
@nl
prefLabel
Do ligand binding and solvent ...... e of an enzymatic active site?
@ast
Do ligand binding and solvent ...... e of an enzymatic active site?
@en
Do ligand binding and solvent ...... e of an enzymatic active site?
@nl
P2860
P50
P356
P1476
Do ligand binding and solvent ...... e of an enzymatic active site?
@en
P2093
Daniel Herschlag
Patrick E Bogard
P2860
P304
12104-12105
P356
10.1021/JA075605A
P407
P577
2007-09-14T00:00:00Z