Fundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymes
about
Enzymatic rate enhancements: a review and perspectivePerspectives on electrostatics and conformational motions in enzyme catalysisEffects of Cavities at the Nicotinamide Binding Site of Liver Alcohol Dehydrogenase on Structure, Dynamics and CatalysisKeep on moving: discovering and perturbing the conformational dynamics of enzymesReflections on the catalytic power of a TIM-barrel.Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis.Using unnatural amino acids to probe the energetics of oxyanion hole hydrogen bonds in the ketosteroid isomerase active site.The evolution of enzyme function in the isomerases.The enzymatic reaction catalyzed by lactate dehydrogenase exhibits one dominant reaction path.Extreme electric fields power catalysis in the active site of ketosteroid isomeraseQuantum delocalization of protons in the hydrogen-bond network of an enzyme active site.The activating oxydianion binding domain for enzyme-catalyzed proton transfer, hydride transfer, and decarboxylation: specificity and enzyme architecture.Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site.Mechanistic Imperatives for Deprotonation of Carbon Catalyzed by Triosephosphate Isomerase: Enzyme-Activation by Phosphite Dianion.In-Cell Enzymology To Probe His-Heme Ligation in Heme Oxygenase Catalysis.Mechanistic and Evolutionary Insights from Comparative Enzymology of Phosphomonoesterases and Phosphodiesterases across the Alkaline Phosphatase SuperfamilyShuffling Active Site Substate Populations Affects Catalytic Activity: The Case of Glucose Oxidase.Enzyme Architecture: The Role of a Flexible Loop in Activation of Glycerol-3-phosphate Dehydrogenase for Catalysis of Hydride Transfer.Promoting Vibrations and the Function of Enzymes. Emerging Theoretical and Experimental Convergence.
P2860
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P2860
Fundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymes
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2013 nî lūn-bûn
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2013 թուականի Մարտին հրատարակուած գիտական յօդուած
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2013 թվականի մարտին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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name
Fundamental challenges in mech ...... e rate enhancements of enzymes
@ast
Fundamental challenges in mech ...... e rate enhancements of enzymes
@en
Fundamental challenges in mech ...... e rate enhancements of enzymes
@en-gb
Fundamental challenges in mech ...... e rate enhancements of enzymes
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Fundamental challenges in mech ...... e rate enhancements of enzymes
@ast
Fundamental challenges in mech ...... e rate enhancements of enzymes
@en
Fundamental challenges in mech ...... e rate enhancements of enzymes
@en-gb
Fundamental challenges in mech ...... e rate enhancements of enzymes
@nl
prefLabel
Fundamental challenges in mech ...... e rate enhancements of enzymes
@ast
Fundamental challenges in mech ...... e rate enhancements of enzymes
@en
Fundamental challenges in mech ...... e rate enhancements of enzymes
@en-gb
Fundamental challenges in mech ...... e rate enhancements of enzymes
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P2860
P356
P1433
P1476
Fundamental challenges in mech ...... e rate enhancements of enzymes
@en
P2093
Aditya Natarajan
P2860
P304
P356
10.1021/BI4000113
P407
P577
2013-03-26T00:00:00Z