Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors. - Wikidata - wikimedia - TriplyDB

Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors.

Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors.

http://www.wikidata.org/entity/Q34700925

about

MicroRNA-regulated viral vectors for gene therapy Progresses towards safe and efficient gene therapy vectors Promising and delivering gene therapies for vision loss Gene therapy of inherited retinal degenerations: prospects and challenges AAV2 delivery of Flt23k intraceptors inhibits murine choroidal neovascularization Advancing therapeutic strategies for inherited retinal degeneration: recommendations from the Monaciano Symposium What Is Next for Retinal Gene Therapy?Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide Gene augmentation for adRP mutations in RHO.Human cone visual pigment deletions spare sufficient photoreceptors to warrant gene therapy Blue cone monochromacy: visual function and efficacy outcome measures for clinical trials.Vector platforms for gene therapy of inherited retinopathies.Targeting channelrhodopsin-2 to ON-bipolar cells with vitreally administered AAV Restores ON and OFF visual responses in blind mice Gene delivery of a viral anti-inflammatory protein to combat ocular inflammation Gene therapy with the caspase activation and recruitment domain reduces the ocular inflammatory response Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsia Controlling AAV Tropism in the Nervous System with Natural and Engineered Capsids.Novel Methodology for Creating Macaque Retinas with Sortable Photoreceptors and Ganglion Cells.Retinal Gene Therapy: Current Progress and Future Prospects.Let There Be Light: Gene and Cell Therapy for Blindness.Impact of Heparan Sulfate Binding on Transduction of Retina by Recombinant Adeno-Associated Virus Vectors AAV-mediated transduction and targeting of retinal bipolar cells with improved mGluR6 promoters in rodents and primates.PAX6 MiniPromoters drive restricted expression from rAAV in the adult mouse retina.Adeno-associated Virus Vectors Efficiently Transduce Mouse and Rabbit Sensory Neurons Coinfected with Herpes Simplex Virus 1 following Peripheral Inoculation.Heparan Sulfate Binding Promotes Accumulation of Intravitreally Delivered Adeno-associated Viral Vectors at the Retina for Enhanced Transduction but Weakly Influences Tropism.Proceedings of the First International Optogenetic Therapies for Vision Symposium.Red-shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina.Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4-/- mouse and bipolar cells in the rd1 mouse and human retina ex vivo.Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection Drug and gene delivery to the back of the eye: from bench to bedside.The Status of RPE65 Gene Therapy Trials: Safety and Efficacy Evaluation of Dose and Safety of AAV7m8 and AAV8BP2 in the Non-Human Primate Retina.Stacking up CRISPR against RNAi for therapeutic gene inhibition.Development of novel AAV serotype 6 based vectors with selective tropism for human cancer cells.Gene therapy to rescue retinal degeneration caused by mutations in rhodopsin.Gene and cell-based therapies for inherited retinal disorders: An update.Rationally designed capsid and transgene cassette of AAV6 vectors for dendritic cell-based cancer immunotherapy.Insight into the mechanisms of enhanced retinal transduction by the engineered AAV2 capsid variant -7m8.

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P2860

Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors.

http://www.wikidata.org/entity/Q34700925

description

2013 nî lūn-bûn

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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2013 թվականի ապրիլին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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Targeting photoreceptors via i ...... l, capsid-mutated AAV vectors.

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Targeting photoreceptors via i ...... l, capsid-mutated AAV vectors.

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Targeting photoreceptors via i ...... l, capsid-mutated AAV vectors.

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Targeting photoreceptors via i ...... l, capsid-mutated AAV vectors.

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Targeting photoreceptors via i ...... l, capsid-mutated AAV vectors.

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Targeting photoreceptors via i ...... l, capsid-mutated AAV vectors.

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Targeting photoreceptors via i ...... l, capsid-mutated AAV vectors.

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Targeting photoreceptors via i ...... l, capsid-mutated AAV vectors.

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Targeting photoreceptors via i ...... l, capsid-mutated AAV vectors.

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Andrea E Ayala

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Christine N Kay

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Daniel Kasuga

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Frank M Dyka

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George V Aslanidi

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Jingfen Sun

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Renee C Ryals

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Sanford L Boye

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P2860

A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells

Adeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity

Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions

Safety and efficacy of gene transfer for Leber's congenital amaurosis

Human RPE65 gene therapy for Leber congenital amaurosis: persistence of early visual improvements and safety at 1 year

Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey

MicroRNA-restricted transgene expression in the retina

Effect of gene therapy on visual function in Leber's congenital amaurosis

AAV-mediated cone rescue in a naturally occurring mouse model of CNGA3-achromatopsia

The human rhodopsin kinase promoter in an AAV5 vector confers rod- and cone-specific expression in the primate retina.

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10.1371/JOURNAL.PONE.0062097

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Mavis Agbandje-McKenna

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2013-04-26T00:00:00Z

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236604364

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Photoreceptor protein

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