Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. - Wikidata - wikimedia - TriplyDB

Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities.

Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities.

http://www.wikidata.org/entity/Q34703179

about

Novel binding motif of ACTH analogues at the melanocortin receptors Melanocortin receptors, melanotropic peptides and penile erection Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor The Melanocortin Receptor System: A Target for Multiple Degenerative Diseases Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies.Solid-phase peptide head-to-side chain cyclodimerization: discovery of C(2)-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors Targeting protein-protein interfaces using macrocyclic peptides.Effects of macrocycle size and rigidity on melanocortin receptor-1 and -5 selectivity in cyclic lactam alpha-melanocyte-stimulating hormone analogs.Melanotropins as drugs for the treatment of obesity and other feeding disorders: potential and problems.Approaches to the rational design of selective melanocortin receptor antagonists.Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold Opioid and melanocortin receptors: do they have overlapping pharmacophores?"Click"-cyclized (68)Ga-labeled peptides for molecular imaging and therapy: synthesis and preliminary in vitro and in vivo evaluation in a melanoma model system.Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists.Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor.Design of cyclized selective melanotropins.Utilize conjugated melanotropins for the earlier diagnosis and treatment of melanoma The first preparative solution phase synthesis of melanotan II.Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-3 receptor agonist versus antagonist activity.

P2860

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P2860

Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities.

http://www.wikidata.org/entity/Q34703179

description

2006 nî lūn-bûn

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2006 թուականի Մարտին հրատարակուած գիտական յօդուած

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2006 թվականի մարտին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Development of cyclic gamma-MS ...... R/hMC5R antagonist activities.

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Development of cyclic gamma-MS ...... R/hMC5R antagonist activities.

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Development of cyclic gamma-MS ...... R/hMC5R antagonist activities.

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type

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Development of cyclic gamma-MS ...... R/hMC5R antagonist activities.

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Development of cyclic gamma-MS ...... R/hMC5R antagonist activities.

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Development of cyclic gamma-MS ...... R/hMC5R antagonist activities.

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Development of cyclic gamma-MS ...... R/hMC5R antagonist activities.

@ast

Development of cyclic gamma-MS ...... R/hMC5R antagonist activities.

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Development of cyclic gamma-MS ...... R/hMC5R antagonist activities.

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Journal of Medicinal Chemistry

P1476

Development of cyclic gamma-MS ...... R/hMC5R antagonist activities.

@en

P2093

Alexander V Mayorov

http://www.w3.org/2001/XMLSchema#string

April R Van Scoy

http://www.w3.org/2001/XMLSchema#string

Dev Trivedi

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Dustin K Tanaka

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Kevin B Chandler

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Minying Cai

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Ravil R Petrov

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Victor J Hruby

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Zerui Yu

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P2860

A role for the melanocortin 4 receptor in sexual function.

The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans

Molecular cloning, expression, and gene localization of a fourth melanocortin receptor

The melanocortin system

Melanocortin-5 receptor deficiency promotes defensive behavior in male mice

Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides

Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

Solution structures of cyclic melanocortin agonists and antagonists by NMR.

Discovery and in vivo evaluation of new melanocortin-4 receptor-selective peptides.

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1946-1952

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scholarly article

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10.1021/JM0510326

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P433

6

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P478

49

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2006-03-01T00:00:00Z

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7240018

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16539382

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1484467

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