Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice. - Wikidata - wikimedia - TriplyDB

Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice.

Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice.

http://www.wikidata.org/entity/Q34707445

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Deficiency of the NR4A orphan nuclear receptor NOR1 in hematopoietic stem cells accelerates atherosclerosis GenomicInteractions: An R/Bioconductor package for manipulating and investigating chromatin interaction data.Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.Skin phototype: a new perspective.Dichotomous roles for the orphan nuclear receptor NURR1 in breast cancer Splicing factor 3b subunit 1 (Sf3b1) haploinsufficient mice display features of low risk Myelodysplastic syndromes with ring sideroblasts.The orphan nuclear receptor NR4A1 specifies a distinct subpopulation of quiescent myeloid-biased long-term HSCs.NR4A2 is regulated by gastrin and influences cellular responses of gastric adenocarcinoma cells.The NR4A2 nuclear receptor is recruited to novel nuclear foci in response to UV irradiation and participates in nucleotide excision repair Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytes.Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and tolerance Genome Wide Mapping of NR4A Binding Reveals Cooperativity with ETS Factors to Promote Epigenetic Activation of Distal Enhancers in Acute Myeloid Leukemia Cells DNA transcription and repair: a confluence Genome-wide profiling reveals transcriptional repression of MYC as a core component of NR4A tumor suppression in acute myeloid leukemia.Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice.NR4A nuclear receptors in immunity and atherosclerosis Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice Nuclear receptor 4A1 (NR4A1) as a drug target for treating rhabdomyosarcoma (RMS).HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML Targeting of polo-like kinases and their cross talk with Aurora kinases--possible therapeutic strategies in human acute myeloid leukemia?MC1R and NR4A receptors in cellular stress and DNA repair: implications for UVR protection.Transcriptional modulation of regulatory T cell development by novel regulators NR4As.Nuclear receptor 4A (NR4A) family - orphans no more.Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia.miRNA-mRNA integrative analysis in primary myelofibrosis CD34+ cells: role of miR-155/JARID2 axis in abnormal megakaryopoiesis.Role of nuclear receptor NR4A2 in gastrointestinal inflammation and cancers.Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition.Longitudinal Analysis of DNA Methylation in CD34+ Hematopoietic Progenitors in Myelodysplastic Syndrome.Tumours of the lacrimal gland. Epidemiological, clinical and genetic characteristics.Drug screening to target nuclear orphan receptor NR4A2 for cancer therapeutics.In vivo murine hepatic microRNA and mRNA expression signatures predicting the (non-)genotoxic carcinogenic potential of chemicals.Identification of a Multipotent Progenitor Population in the Spleen That Is Regulated by NR4A1.Reduced expression of NR4A1 activates glycolytic pathway in acute promyelocytic leukemia cells.NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling.Modulating impact of human chorionic gonadotropin hormone on the maturation and function of hematopoietic cells.Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome.SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death.Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma.

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P2860

Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice.

http://www.wikidata.org/entity/Q34707445

description

2011 nî lūn-bûn

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Reduced NR4A gene dosage leads ...... oliferative neoplasms in mice.

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Reduced NR4A gene dosage leads ...... oliferative neoplasms in mice.

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Reduced NR4A gene dosage leads ...... oliferative neoplasms in mice.

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type

label

Reduced NR4A gene dosage leads ...... oliferative neoplasms in mice.

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Reduced NR4A gene dosage leads ...... oliferative neoplasms in mice.

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Reduced NR4A gene dosage leads ...... oliferative neoplasms in mice.

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prefLabel

Reduced NR4A gene dosage leads ...... oliferative neoplasms in mice.

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Reduced NR4A gene dosage leads ...... oliferative neoplasms in mice.

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Reduced NR4A gene dosage leads ...... oliferative neoplasms in mice.

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Reduced NR4A gene dosage leads ...... oliferative neoplasms in mice.

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Andrea M Sheehan

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Ashley M Ramirez-Herrick

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Orla M Conneely

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Shannon E Mullican

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P2860

Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation

Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells

A short Nur77-derived peptide converts Bcl-2 from a protector to a killer

The NR4A subgroup: immediate early response genes with pleiotropic physiological roles

Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells

Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nurr-1 in the adrenal glands

The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle

Identification of a new brain-specific transcription factor, NURR1

Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine

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