Mechanism of intramembrane cleavage of alcadeins by γ-secretase. - Wikidata - wikimedia - TriplyDB

Mechanism of intramembrane cleavage of alcadeins by γ-secretase.

Mechanism of intramembrane cleavage of alcadeins by γ-secretase.

http://www.wikidata.org/entity/Q34712076

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Cytoplasmic fragment of Alcadein α generated by regulated intramembrane proteolysis enhances amyloid β-protein precursor (APP) transport into the late secretory pathway and facilitates APP cleavage.Specific Triazine Herbicides Induce Amyloid-β42 Production.Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase.Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E.Phosphorylation of multiple sites within an acidic region of Alcadein α is required for kinesin-1 association and Golgi exit of Alcadein α cargo.

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Mechanism of intramembrane cleavage of alcadeins by γ-secretase.

http://www.wikidata.org/entity/Q34712076

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2013 nî lūn-bûn

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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2013 թվականի ապրիլին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Mechanism of intramembrane cleavage of alcadeins by γ-secretase.

@ast

Mechanism of intramembrane cleavage of alcadeins by γ-secretase.

@en

Mechanism of intramembrane cleavage of alcadeins by γ-secretase.

@nl

type

label

Mechanism of intramembrane cleavage of alcadeins by γ-secretase.

@ast

Mechanism of intramembrane cleavage of alcadeins by γ-secretase.

@en

Mechanism of intramembrane cleavage of alcadeins by γ-secretase.

@nl

prefLabel

Mechanism of intramembrane cleavage of alcadeins by γ-secretase.

@ast

Mechanism of intramembrane cleavage of alcadeins by γ-secretase.

@en

Mechanism of intramembrane cleavage of alcadeins by γ-secretase.

@nl

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JOURNAL.PONE.0062431

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Mechanism of intramembrane cleavage of alcadeins by γ-secretase.

@en

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Ayano Kimura

http://www.w3.org/2001/XMLSchema#string

Hidenori Taru

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Saori Hata

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Satomi Urano

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Tohru Yamamoto

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Toshiharu Suzuki

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Yi Piao

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Yuhki Saito

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P2860

Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation

The same gamma-secretase accounts for the multiple intramembrane cleavages of APP

Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction.

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.

Translating cell biology into therapeutic advances in Alzheimer's disease.

Intramembrane proteolysis: theme and variations.

γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43.

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

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