Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.
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The Alzheimer's amyloid-degrading peptidase, neprilysin: can we control it?A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signalingThe amyloid-beta precursor protein: integrating structure with biological functionA novel mechanism for the regulation of amyloid precursor protein metabolismGleevec inhibits beta-amyloid production but not Notch cleavageReduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 alleleDeletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's diseaseEffect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer's disease (review)General anesthetics and β-amyloid proteinAutoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processingProteolytic processing of Alzheimer's β-amyloid precursor proteinTransgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer's Disease-like traits in vivoInsulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus.Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.Nitrous oxide plus isoflurane induces apoptosis and increases beta-amyloid protein levelsThe intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain.Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 productionBeta-secretase: structure, function, and evolution.Transient axonal glycoprotein-1 induces apoptosis-related gene expression without triggering apoptosis in U251 glioma cellsAlleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2.The pathogenic aβ43 is enriched in familial and sporadic Alzheimer diseaseA synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase.Mechanism of intramembrane cleavage of alcadeins by γ-secretase.Presenilin-dependent intramembrane cleavage of ephrin-B1.Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease.Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles.Presenilin function and gamma-secretase activity.The GxxxG motif in the transmembrane domain of AbetaPP plays an essential role in the interaction of CTF beta with the gamma-secretase complex and the formation of amyloid-betaActivation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain.RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing.The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloidThe inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditionsInteractome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional roleThe common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivoA helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis.
P2860
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P2860
Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Characterization of a presenil ...... Notch1 transmembrane domains.
@ast
Characterization of a presenil ...... Notch1 transmembrane domains.
@en
type
label
Characterization of a presenil ...... Notch1 transmembrane domains.
@ast
Characterization of a presenil ...... Notch1 transmembrane domains.
@en
prefLabel
Characterization of a presenil ...... Notch1 transmembrane domains.
@ast
Characterization of a presenil ...... Notch1 transmembrane domains.
@en
P2093
P2860
P356
P1476
Characterization of a presenil ...... Notch1 transmembrane domains.
@en
P2093
L Gasparini
S S Sisodia
P2860
P304
43756-43760
P356
10.1074/JBC.C100410200
P407
P577
2001-10-02T00:00:00Z