The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis. - Wikidata - wikimedia - TriplyDB

The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis.

The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis.

http://www.wikidata.org/entity/Q34720182

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Pharmacological implications of the Ca(2+)/cAMP signaling interaction: from risk for antihypertensive therapy to potential beneficial for neurological and psychiatric disorders Flow "Fine" Synthesis: High Yielding and Selective Organic Synthesis by Flow Methods The TLR and IL-1 signalling network at a glance COX-2 inhibitors vs. NSAIDs in gastrointestinal damage and prevention Inhibition of phosphodiesterase type IV suppresses human immunodeficiency virus type 1 replication and cytokine production in primary T cells: involvement of NF-kappaB and NFAT The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice Enhancement of the anti-inflammatory and anti-arthritic effects of theophylline by a low dose of a nitric oxide donor or non-specific nitric oxide synthase inhibitor Tolerance and autoimmunity in TCR transgenic mice specific for myelin basic protein.IL-12 as a therapeutic target for pharmacological modulation in immune-mediated and inflammatory diseases: regulation of T helper 1/T helper 2 responses Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha The role of TNFalpha and lymphotoxin in demyelinating disease.Tumour necrosis factor and anti-tumour necrosis factor approach to inflammatory demyelinating diseases of the central nervous system.Depression in medical illness: the role of the immune system.Drugs, inflammation and cell adhesion receptors.Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes.Identification of new therapeutic targets for prevention of CNS inflammation.Treatment with the phosphodiesterase type-4 inhibitor rolipram fails to inhibit blood--brain barrier disruption in multiple sclerosis.Disease-modifying therapies in multiple sclerosis: an update on recent and ongoing trials and future strategies.Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy.Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states.Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate.PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms The therapeutic potential of CXC chemokine blockade in acute inflammation in the brain.Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury.An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease.Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitis.Combination therapy of lovastatin and rolipram provides neuroprotection and promotes neurorepair in inflammatory demyelination model of multiple sclerosis.Regulation of proinflammatory cytokine expression in primary mouse astrocytes by coronavirus infection Phosphodiesterase inhibitors as therapeutics for traumatic brain injury.Pathogenesis and treatment of human T-cell lymphotropic virus Type I-associated myelopathy.Roflumilast inhibits leukocyte-endothelial cell interactions, expression of adhesion molecules and microvascular permeability.Vinpocetine inhibits oligodendroglial precursor cell differentiation.Multiple sclerosis: TNF revisited, with promise.Insulin-like growth factor-I treatment reduces immune cell responses in acute non-demyelinative experimental autoimmune encephalomyelitis.Postulated vasoactive neuropeptide immunopathology affecting the blood-brain/blood-spinal barrier in certain neuropsychiatric fatigue-related conditions: A role for phosphodiesterase inhibitors in treatment?Introductory remarks: immunosuppressive and immunomodulating drugs, where and how do they act?Inhibitors of tumor necrosis factor-alpha: promising agents for the treatment of multiple sclerosis?The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain.

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The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis.

http://www.wikidata.org/entity/Q34720182

description

1995 nî lūn-bûn

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1995 թուականի Մարտին հրատարակուած գիտական յօդուած

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1995 թվականի մարտին հրատարակված գիտական հոդված

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The antidepressant rolipram su ...... autoimmune encephalomyelitis.

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The antidepressant rolipram su ...... autoimmune encephalomyelitis.

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The antidepressant rolipram su ...... autoimmune encephalomyelitis.

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The antidepressant rolipram su ...... autoimmune encephalomyelitis.

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The antidepressant rolipram su ...... autoimmune encephalomyelitis.

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The antidepressant rolipram su ...... autoimmune encephalomyelitis.

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The antidepressant rolipram su ...... autoimmune encephalomyelitis.

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The antidepressant rolipram su ...... autoimmune encephalomyelitis.

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Nature Medicine

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The antidepressant rolipram su ...... autoimmune encephalomyelitis.

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P2093

Fontana A

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Lichtenfels R

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Löschmann PA

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Meyermann R

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Northoff GH

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Riethmüller A

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Steinbach JP

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Weller M

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P2860

Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors.

Exacerbations of multiple sclerosis in patients treated with gamma interferon.

A new cyclic nucleotide phosphodiesterase isozyme expressed in the T-lymphocyte cell lines.

Experimental allergic encephalomyelitis.

Rolipram, a novel antidepressant drug, reverses the hypothermia and hypokinesia of monoamine-depleted mice by an action beyond postsynaptic monoamine receptors.

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244-248

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10.1038/NM0395-244

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1013520596

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7585041

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