BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin. - Wikidata - wikimedia - TriplyDB

BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.

BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.

http://www.wikidata.org/entity/Q34752500

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Sortilin, encoded by the cardiovascular risk gene SORT1, and its suggested functions in cardiovascular disease A Genetic Variant of the Sortilin 1 Gene is Associated with Reduced Risk of Alzheimer's Disease The normal and pathologic roles of the Alzheimer's β-secretase, BACE1 Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease.Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2 Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.Advances with RNA interference in Alzheimer's disease research.Dysregulation of protein trafficking in neurodegeneration.The intracellular domain of sortilin interacts with amyloid precursor protein and regulates its lysosomal and lipid raft trafficking The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking(1,2,3).Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons VPS35 regulates developing mouse hippocampal neuronal morphogenesis by promoting retrograde trafficking of BACE1 The role of intracellular trafficking and the VPS10d receptors in Alzheimer's disease.Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes.Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.β-Secretase: its biology as a therapeutic target in diseases The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation.Phenotypic assays for β-amyloid in mouse embryonic stem cell-derived neurons Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme 1.RNA silencing of genes involved in Alzheimer's disease enhances mitochondrial function and synaptic activity.The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease.Intracellular trafficking of the β-secretase and processing of amyloid precursor protein.Identification and biology of β-secretase.The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond Retromers in Alzheimer's disease.Apolipoprotein E receptor pathways in Alzheimer disease.Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases.Informatics Support for Basic Research in Biomedicine.The Role of Retromer in Alzheimer's Disease.Amyloid beta₁₋₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75(NTR)/RhoA signaling pathway.Retromer regulates postendocytic sorting of β-secretase in polarized Madin-Darby canine kidney cells.Prions amplify through degradation of the VPS10P sorting receptor sortilin.Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson's disease mutant of Leucine-Rich Repeat Kinase 2 (LRRK2).The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release.Sortilin limits EGFR signaling by promoting its internalization in lung cancer.Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production.

P2860

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P2860

BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.

http://www.wikidata.org/entity/Q34752500

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.

@ast

BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.

@en

BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.

@nl

type

label

BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.

@ast

BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.

@en

BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.

@nl

prefLabel

BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.

@ast

BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.

@en

BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.

@nl

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JBC.M110.170217

P1433

Journal of Biological Chemistry

P1476

BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.

@en

P2093

Gina M Finan

http://www.w3.org/2001/XMLSchema#string

Hirokazu Okada

http://www.w3.org/2001/XMLSchema#string

Tae-Wan Kim

http://www.w3.org/2001/XMLSchema#string

P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Purification and cloning of amyloid precursor protein beta-secretase from human brain

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme

SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer

Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor

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12602-12616

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scholarly article

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10.1074/JBC.M110.170217

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14

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286

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21245145

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3069461

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