MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.
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The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activityA noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasisMultiple phosphorylation events control mitotic degradation of the muscle transcription factor Myf5.Extracellular signal-regulated kinases 1/2 as regulators of cardiac hypertrophyA systematic interaction map of validated kinase inhibitors with Ser/Thr kinasesMembrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha-mediated activation of ERK signaling.Induction of brain natriuretic peptide and monocyte chemotactic protein-1 gene expression by oxidized low-density lipoprotein: relevance to ischemic heart failureActivation of JNK triggers release of Brd4 from mitotic chromosomes and mediates protection from drug-induced mitotic stressThe complex of ciliary neurotrophic factor-ciliary neurotrophic factor receptor alpha up-regulates connexin43 and intercellular coupling in astrocytes via the Janus tyrosine kinase/signal transducer and activator of transcription pathwayMitogen-activated protein kinase (MAPK/ERK) regulates adenomatous polyposis coli during growth-factor-induced cell extensionInvolvement of protein kinase C-dependent mitogen-activated protein kinase p44/42 signaling pathway for cross-talk between estradiol and transforming growth factor-beta3 in increasing basic fibroblast growth factor in folliculostellate cellsFATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity.Experimental and Computational Analysis of a Large Protein Network That Controls Fat Storage Reveals the Design Principles of a Signaling NetworkActivation of Erk by sonic hedgehog independent of canonical hedgehog signalling.The Concise Guide to PHARMACOLOGY 2013/14: enzymes.Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states.Fibroblast growth factor 2 causes G2/M cell cycle arrest in ras-driven tumor cells through a Src-dependent pathway.The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafishChemical reprogramming of Caenorhabditis elegans germ cell fateAnti-inflammatory mechanism of polyunsaturated fatty acids in Helicobacter pylori-infected gastric epithelial cells.Protection of cells in physiological oxygen tensions against DNA damage-induced apoptosisMediation of basic fibroblast growth factor-induced lactotropic cell proliferation by Src-Ras-mitogen-activated protein kinase p44/42 signaling.Alternative splicing of human papillomavirus type-16 E6/E6* early mRNA is coupled to EGF signaling via Erk1/2 activation.7-Ketocholesterol-induced inflammation signals mostly through the TLR4 receptor both in vitro and in vivo.PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cellsProbing the probes: fitness factors for small molecule tools.Geniposide, the component of the Chinese herbal formula Tongluojiunao, protects amyloid-β peptide (1-42-mediated death of hippocampal neurons via the non-classical estrogen signaling pathway.Phosphorylation of the Drosophila melanogaster RNA-binding protein HOW by MAPK/ERK enhances its dimerization and activityERK activation is required for CCK-mediated pancreatic adaptive growth in mice.Opioid-induced mitogen-activated protein kinase signaling in rat enteric neurons following chronic morphine treatment.GDNF family ligands trigger indirect neuroprotective signaling in retinal glial cellsDevelopment of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases.High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy.A computational framework for the topological analysis and targeted disruption of signal transduction networks.Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels.Oncogenic Kras promotes chemotherapy-induced growth factor shedding via ADAM17Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide.U0126 protects cells against oxidative stress independent of its function as a MEK inhibitor.Poxviral regulation of the host NF-kappaB response: the vaccinia virus M2L protein inhibits induction of NF-kappaB activation via an ERK2 pathway in virus-infected human embryonic kidney cells.Function of phosphoenolpyruvate carboxykinase in mammary gland epithelial cells.
P2860
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P2860
MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.
description
1998 nî lūn-bûn
@nan
1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
MEK inhibitors: the chemistry ...... ogs, and cyclization products.
@ast
MEK inhibitors: the chemistry ...... ogs, and cyclization products.
@en
MEK inhibitors: the chemistry ...... ogs, and cyclization products.
@nl
type
label
MEK inhibitors: the chemistry ...... ogs, and cyclization products.
@ast
MEK inhibitors: the chemistry ...... ogs, and cyclization products.
@en
MEK inhibitors: the chemistry ...... ogs, and cyclization products.
@nl
prefLabel
MEK inhibitors: the chemistry ...... ogs, and cyclization products.
@ast
MEK inhibitors: the chemistry ...... ogs, and cyclization products.
@en
MEK inhibitors: the chemistry ...... ogs, and cyclization products.
@nl
P2093
P1476
MEK inhibitors: the chemistry ...... ogs, and cyclization products.
@en
P2093
Copeland RA
Daulerio AJ
Frietze WE
Horiuchi K
P304
P356
10.1016/S0960-894X(98)00522-8
P407
P577
1998-10-01T00:00:00Z