Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling - Wikidata - wikimedia - TriplyDB

Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling

Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling

http://www.wikidata.org/entity/Q34764696

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Biomarkers and Targeted Therapy in Pancreatic Cancer Genetics and biology of pancreatic ductal adenocarcinoma Targeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitors The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.The role of Cdk5 in neuroendocrine thyroid cancer Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis Regulation of androgen receptor and prostate cancer growth by cyclin-dependent kinase 5 Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia.First BRET-based screening assay performed in budding yeast leads to the discovery of CDK5/p25 interaction inhibitors.Oncogenic KRAS signalling in pancreatic cancer.Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration Discovery of thienoquinolone derivatives as selective and ATP non-competitive CDK5/p25 inhibitors by structure-based virtual screening Nestin predicts a favorable prognosis in early ampullary adenocarcinoma and functions as a promoter of metastasis in advanced cancer.CDK5 is a major regulator of the tumor suppressor DLC1 Genome-wide promoter methylome of small renal masses.The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery.Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression.CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis.Bioinformatics Knowledge Map for Analysis of Beta-Catenin Function in Cancer.Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis.Computational identification and modeling of crosstalk between phosphorylation, O-β-glycosylation and methylation of FoxO3 and implications for cancer therapeutics.Insights into the clinical value of cyclin-dependent kinase 5 in glioma: a retrospective study.Cyclin-Dependent Kinase 5 (CDK5) Controls Melanoma Cell Motility, Invasiveness, and Metastatic Spread-Identification of a Promising Novel therapeutic target.Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy Achaete-scute homologue-1 (ASH1) stimulates migration of lung cancer cells through Cdk5/p35 pathway.Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-Ras Cyclin-Dependent Kinase Inhibitors as Anticancer Therapeutics Phosphoregulation of the RNA-binding protein Hu antigen R (HuR) by Cdk5 affects centrosome function.Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma Retinoic Acid Induces Apoptosis of Prostate Cancer DU145 Cells through Cdk5 Overactivation MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma.The BEAF insulator regulates genes involved in cell polarity and neoplastic growth.Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis.Low Expression of CDK5 and p27 Are Associated with Poor Prognosis in Patients with Gastric Cancer.Evaluation and clinical significance of cyclin-dependent kinase5 expression in cervical lesions: a clinical research study in Guangxi, China CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression.Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity Cyclin-dependent kinase 5 stabilizes hypoxia-inducible factor-1α: a novel approach for inhibiting angiogenesis in hepatocellular carcinoma.

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Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling

http://www.wikidata.org/entity/Q34764696

description

2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Inhibiting the cyclin-dependen ...... ppression of Ras-Ral signaling

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Inhibiting the cyclin-dependen ...... ppression of Ras-Ral signaling

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Inhibiting the cyclin-dependen ...... ppression of Ras-Ral signaling

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Inhibiting the cyclin-dependen ...... ppression of Ras-Ral signaling

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Inhibiting the cyclin-dependen ...... ppression of Ras-Ral signaling

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Inhibiting the cyclin-dependen ...... ppression of Ras-Ral signaling

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Inhibiting the cyclin-dependen ...... ppression of Ras-Ral signaling

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0008-5472.CAN-09-1107

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Cancer Research

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Inhibiting the cyclin-dependen ...... ppression of Ras-Ral signaling

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Anjali Mishra

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Barry D Nelkin

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Christopher J Strock

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Douglas W Ball

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Georg Feldmann

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Savita Bisht

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P2860

Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases

PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo

Cancer statistics, 2008

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

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11

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70

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Michael Goggins

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2010-05-18T00:00:00Z

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20484029

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3071300

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