Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties.
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Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disordersIn vivo evaluation of alpha7 nicotinic acetylcholine receptor agonists [11C]A-582941 and [11C]A-844606 in mice and conscious monkeysChemical chaperones exceed the chaperone effects of RIC-3 in promoting assembly of functional α7 AChRsDeletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's diseasenAChR dysfunction as a common substrate for schizophrenia and comorbid nicotine addiction: Current trends and perspectives.TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia.The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model.Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Δ2-isoxazoline derivatives as potent and selective agonists of α7 nicotinic acetylcholine receptors.Decreasing nicotinic receptor activity and the spatial learning impairment caused by the NMDA glutamate antagonist dizocilpine in rats.Brain imaging of nicotinic receptors in Alzheimer's disease.α7 Nicotinic Receptor Agonists: Potential Therapeutic Drugs for Treatment of Cognitive Impairments in Schizophrenia and Alzheimer's Disease.Pharmacological enhancement of memory and executive functioning in laboratory animals.The effects of aging vs. α7 nAChR subunit deficiency on the mouse brain transcriptome: aging beats the deficiency.Cancer 'survivor-care': I. the α7 nAChR as potential target for chemotherapy-related cognitive impairment.The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia.Pro-cognitive activity in rats of 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptorEpinephrine and glucose modulate training-related CREB phosphorylation in old rats: relationships to age-related memory impairments.Occupancy of α7 Nicotinic Acetylcholine Receptors in the Brain by Tropisetron: A Positron Emission Tomography Study Using [(11)C]CHIBA-1001 in Healthy Human SubjectsNicotinic receptors in neurodegeneration.Cholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: an overview of preclinical and clinical findings.Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia.The therapeutic potential of α7 nicotinic acetylcholine receptor (α7 nAChR) agonists for the treatment of the cognitive deficits associated with schizophrenia.Role of channel activation in cognitive enhancement mediated by alpha7 nicotinic acetylcholine receptors.Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1.Radioligand binding characterization of neuronal nicotinic acetylcholine receptors.Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625.Type I and II positive allosteric modulators differentially modulate agonist-induced up-regulation of α7 nicotinic acetylcholine receptors.Stimulation of nicotinic acetylcholine alpha7 receptors rescue schizophrenia-like cognitive impairments in rats.Effects of α7 nicotinic acetylcholine receptor agonists on antipsychotic efficacy in a preclinical mouse model of psychosis.
P2860
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P2860
Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Preclinical characterization o ...... ognition-enhancing properties.
@ast
Preclinical characterization o ...... ognition-enhancing properties.
@en
Preclinical characterization o ...... ognition-enhancing properties.
@nl
type
label
Preclinical characterization o ...... ognition-enhancing properties.
@ast
Preclinical characterization o ...... ognition-enhancing properties.
@en
Preclinical characterization o ...... ognition-enhancing properties.
@nl
prefLabel
Preclinical characterization o ...... ognition-enhancing properties.
@ast
Preclinical characterization o ...... ognition-enhancing properties.
@en
Preclinical characterization o ...... ognition-enhancing properties.
@nl
P2093
P2860
P1476
Preclinical characterization o ...... ognition-enhancing properties.
@en
P2093
Angela L Molesky
Arthur L Nikkel
Clark A Briggs
Dagmar Bury
David J Anderson
Devalina Law
Earl J Gubbins
Eric A Blomme
Gerard B Fox
P2860
P356
10.1111/J.1755-5949.2008.00037.X
P577
2008-01-01T00:00:00Z