p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice
about
Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiationThe cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cellsPALB2 regulates recombinational repair through chromatin association and oligomerizationPhospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damageBRCTx is a novel, highly conserved RAD18-interacting proteinDNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formationHuman Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancersFunctional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrestTP53-binding protein variants and breast cancer risk: a case-control studyMechanisms of benzene-induced hematotoxicity and leukemogenicity: cDNA microarray analyses using mouse bone marrow tissue.PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcriptionDouble-strand break repair on sex chromosomes: challenges during male meiotic prophaseStructural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair53BP1 regulates DSB repair using Rif1 to control 5' end resectionA selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiencyThe response to and repair of RAG-mediated DNA double-strand breaksEDD mediates DNA damage-induced activation of CHK2Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesisA chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouseA mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpointp53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening systemThe RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination53BP1 is required for class switch recombination.RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integritySystematic Discovery of In Vivo Phosphorylation NetworksBLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination.BRIT1 regulates early DNA damage response, chromosomal integrity, and cancerBRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice.Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.The p53-binding protein 1-Tudor-interacting repair regulator complex participates in the DNA damage response.USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism.Poly (ADP-ribose) polymerase inhibitor, an effective radiosensitizer in lung and pancreatic cancers.BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis.{Delta}Np73{beta} puts the brakes on DNA repair.Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathwayBeclin 1 and UVRAG confer protection from radiation-induced DNA damage and maintain centrosome stability in colorectal cancer cells53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination.Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.
P2860
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P2860
p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
p53 Binding protein 53BP1 is r ...... and tumor suppression in mice
@ast
p53 Binding protein 53BP1 is r ...... and tumor suppression in mice
@en
p53 Binding protein 53BP1 is r ...... and tumor suppression in mice
@nl
type
label
p53 Binding protein 53BP1 is r ...... and tumor suppression in mice
@ast
p53 Binding protein 53BP1 is r ...... and tumor suppression in mice
@en
p53 Binding protein 53BP1 is r ...... and tumor suppression in mice
@nl
prefLabel
p53 Binding protein 53BP1 is r ...... and tumor suppression in mice
@ast
p53 Binding protein 53BP1 is r ...... and tumor suppression in mice
@en
p53 Binding protein 53BP1 is r ...... and tumor suppression in mice
@nl
P2093
P2860
P1476
p53 Binding protein 53BP1 is r ...... and tumor suppression in mice
@en
P2093
Irene M Ward
Jan van Deursen
Junjie Chen
P2860
P304
P356
10.1128/MCB.23.7.2556-2563.2003
P407
P577
2003-04-01T00:00:00Z