Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.
about
A novel volume-age-KPS (VAK) glioblastoma classification identifies a prognostic cognate microRNA-gene signatureThe E3 ligase RNF8 regulates KU80 removal and NHEJ repairDynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsBMI1-mediated histone ubiquitylation promotes DNA double-strand break repairChoreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear ArchitectureFine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at workMammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrityPTIP promotes chromatin changes critical for immunoglobulin class switch recombinationDNA-damage response and repair activities at uncapped telomeres depend on RNF8The histone methyltransferase MMSET regulates class switch recombinationDouble strand break repair functions of histone H2AXUSP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism.Histone H2A and H2B are monoubiquitinated at AID-targeted loci.The role of E3 ligases in the ubiquitin-dependent regulation of spermatogenesisThe role of histone ubiquitination during spermatogenesis.Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndromeThe intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0.Mutation screening of the RNF8, UBC13 and MMS2 genes in Northern Finnish breast cancer families.The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.Role of Pirh2 in mediating the regulation of p53 and c-Myc.Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis.DNA double-strand break signaling and human disorders.Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity.Ubiquitin makes its mark on immune regulation.Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2.RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesisCritical roles of ring finger protein RNF8 in replication stress responses.Chfr and RNF8 synergistically regulate ATM activation.RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage.Mice lacking the USP2 deubiquitinating enzyme have severe male subfertility associated with defects in fertilization and sperm motility.miR-214-mediated downregulation of RNF8 induces chromosomal instability in ovarian cancer cellsImmunoglobulin class-switch DNA recombination: induction, targeting and beyond.Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.RNF4 is required for DNA double-strand break repair in vivo.RNF168 forms a functional complex with RAD6 during the DNA damage responseAdenovirus-mediated downregulation of the ubiquitin ligase RNF8 sensitizes bladder cancer to radiotherapy.Determining timing of hepatectomy for colorectal cancer with distant metastasis according to imaging-based tumor shrinkage ratio.RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination.
P2860
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P2860
Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Rnf8 deficiency impairs class ...... ty and predisposes for cancer.
@ast
Rnf8 deficiency impairs class ...... ty and predisposes for cancer.
@en
type
label
Rnf8 deficiency impairs class ...... ty and predisposes for cancer.
@ast
Rnf8 deficiency impairs class ...... ty and predisposes for cancer.
@en
prefLabel
Rnf8 deficiency impairs class ...... ty and predisposes for cancer.
@ast
Rnf8 deficiency impairs class ...... ty and predisposes for cancer.
@en
P2093
P2860
P50
P356
P1476
Rnf8 deficiency impairs class ...... ty and predisposes for cancer.
@en
P2093
Anne Hakem
Marie-Jo Halaby
Norman Chan
Otto Sanchez
Razqallah Hakem
Renato Cardoso
Samah El Ghamrasni
P2860
P304
P356
10.1084/JEM.20092437
P407
P577
2010-04-12T00:00:00Z