Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation
about
Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humansMultiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5ACaMKII-dependent regulation of cardiac Na(+) homeostasisDeterminants of incomplete penetrance and variable expressivity in heritable cardiac arrhythmia syndromesCrystallographic basis for calcium regulation of sodium channelsSodium channel mutations and susceptibility to heart failure and atrial fibrillationInherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels.Tpeak-Tend and Tpeak-Tend dispersion as risk factors for ventricular tachycardia/ventricular fibrillation in patients with the Brugada syndrome.The cardiac sodium channel mutation delQKP 1507-1509 is associated with the expanding phenotypic spectrum of LQT3, conduction disorder, dilated cardiomyopathy, and high incidence of youth sudden deathTorsades de pointes during complete atrioventricular block: Genetic factors and electrocardiogram correlates.Recent developments in the management of patients at risk for sudden cardiac death.The role of ion channelopathies in sudden cardiac death: implications for clinical practice.p.Y1449C SCN5A mutation associated with overlap disorder comprising conduction disease, Brugada syndrome, and atrial flutter.Cardiac Na Channels: Structure to FunctionAlternative splicing of the cardiac sodium channel creates multiple variants of mutant T1620K channels.Unraveling monogenic channelopathies and their implications for complex polygenic diseaseInherited disorders of voltage-gated sodium channels.Cardiac sodium channelopathies.Dual variation in SCN5A and CACNB2b underlies the development of cardiac conduction disease without Brugada syndrome.Sudden cardiac death and inherited channelopathy: the basic electrophysiology of the myocyte and myocardium in ion channel disease.A heterozygous deletion mutation in the cardiac sodium channel gene SCN5A with loss- and gain-of-function characteristics manifests as isolated conduction disease, without signs of Brugada or long QT syndrome.Defective cardiac ion channels: from mutations to clinical syndromes.A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes.The mitochondrial DNA mutations associated with cardiac arrhythmia investigated in an LQTS family.The genetic basis for inherited forms of sinoatrial dysfunction and atrioventricular node dysfunctionAltered sinoatrial node function and intra-atrial conduction in murine gain-of-function Scn5a+/ΔKPQ hearts suggest an overlap syndrome.Functional expression of "cardiac-type" Nav1.5 sodium channel in canine intracardiac ganglia.Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation.Delayed afterdepolarizations generate both triggers and a vulnerable substrate promoting reentry in cardiac tissueA novel C-terminal truncation SCN5A mutation from a patient with sick sinus syndrome, conduction disorder and ventricular tachycardiaElectrophysiological basis and genetics of Brugada syndrome.Wide spectrum of inhibitory effects of sertraline on cardiac ion channelsApplication of cardiac electrophysiology simulations to pro-arrhythmic safety testing.Novel deletion mutation in the cardiac sodium channel inactivation gate causes long QT syndromeThe E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome.Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation.Gender-based differences in cardiac diseasesA common SCN5A polymorphism attenuates a severe cardiac phenotype caused by a nonsense SCN5A mutation in a Chinese family with an inherited cardiac conduction defectCorticosteroids Are Essential for Maintaining Cardiovascular Function in Male Mice.Channelopathies in children and adults.
P2860
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P2860
Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Long QT syndrome, Brugada synd ...... single sodium channel mutation
@ast
Long QT syndrome, Brugada synd ...... single sodium channel mutation
@en
Long QT syndrome, Brugada synd ...... single sodium channel mutation
@nl
type
label
Long QT syndrome, Brugada synd ...... single sodium channel mutation
@ast
Long QT syndrome, Brugada synd ...... single sodium channel mutation
@en
Long QT syndrome, Brugada synd ...... single sodium channel mutation
@nl
prefLabel
Long QT syndrome, Brugada synd ...... single sodium channel mutation
@ast
Long QT syndrome, Brugada synd ...... single sodium channel mutation
@en
Long QT syndrome, Brugada synd ...... single sodium channel mutation
@nl
P2093
P2860
P356
P1476
Long QT syndrome, Brugada synd ...... single sodium channel mutation
@en
P2093
Augustus O Grant
C Frank Starmer
Carlo Napolitano
Michael P Carboni
Mirella Memmi
Valentina Neplioueva
P2860
P304
P356
10.1172/JCI0215570
P407
P577
2002-10-01T00:00:00Z