The hidden energetics of ligand binding and activation in a glutamate receptor
about
Functional insights from glutamate receptor ion channel structuresEmerging models of glutamate receptor ion channel structure and functionComputational study of synthetic agonist ligands of ionotropic glutamate receptorsMechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONSBlind Prediction of Charged Ligand Binding Affinities in a Model Binding SiteA Conformational Intermediate in Glutamate Receptor ActivationConformational Analysis of NMDA Receptor GluN1, GluN2, and GluN3 Ligand-Binding Domains Reveals Subtype-Specific CharacteristicsP-loop conformation governed crizotinib resistance in G2032R-mutated ROS1 tyrosine kinase: clues from free energy landscapeNovel inhibitors induce large conformational changes of GAB1 pleckstrin homology domain and kill breast cancer cellsGluN1-specific redox effects on the kinetic mechanism of NMDA receptor activationProtein-Ligand Electrostatic Binding Free Energies from Explicit and Implicit SolvationBlacks' Death Rate Due to Circulatory Diseases Is Positively Related to Whites' Explicit Racial Bias.Role of the Ion Channel Extracellular Collar in AMPA Receptor GatingEquilibrium fluctuations of a single folded protein reveal a multitude of potential cryptic allosteric sites.Stargazin promotes closure of the AMPA receptor ligand-binding domainStructure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized statesReduced curvature of ligand-binding domain free-energy surface underlies partial agonism at NMDA receptors.The molecular mechanism of ion-dependent gating in secondary transporters.Role of cross-cleft contacts in NMDA receptor gatingLigand photo-isomerization triggers conformational changes in iGluR2 ligand binding domainStructure of an agonist-bound ionotropic glutamate receptorFree energy simulations of ligand binding to the aspartate transporter Glt(Ph).Emerging structural insights into the function of ionotropic glutamate receptors.Structural Determinants for the Binding of Morphinan Agonists to the μ-Opioid ReceptorCooperative Dynamics of Intact AMPA and NMDA Glutamate Receptors: Similarities and Subfamily-Specific Differences.Atomistic mechanism for the activation and desensitization of an AMPA-subtype glutamate receptorCHARMM-GUI Ligand Binder for absolute binding free energy calculations and its applicationEstimation of ligand efficacies of metabotropic glutamate receptors from conformational forces obtained from molecular dynamics simulations.Conformational Selection and Submillisecond Dynamics of the Ligand-binding Domain of the N-Methyl-d-aspartate ReceptorCalculating the sensitivity and robustness of binding free energy calculations to force field parameters.Efficient determination of protein-protein standard binding free energies from first principles.Calculating the binding free energies of charged species based on explicit-solvent simulations employing lattice-sum methods: an accurate correction scheme for electrostatic finite-size effectsMolecular lock regulates binding of glycine to a primitive NMDA receptor.Structure and gating of tetrameric glutamate receptors.How to build the fastest receptor on earth.Computational Membrane Biophysics: From Ion Channels Interactions with Drugs to Cellular Function.Dynamics of the Ligand Binding Domain Layer during AMPA Receptor Activation.Attach-Pull-Release Calculations of Ligand Binding and Conformational Changes on the First BRD4 Bromodomain.Structural mechanisms of activation and desensitization in neurotransmitter-gated ion channels.Computational Approaches to the Chemical Equilibrium Constant in Protein-ligand Binding.
P2860
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P2860
The hidden energetics of ligand binding and activation in a glutamate receptor
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The hidden energetics of ligand binding and activation in a glutamate receptor
@ast
The hidden energetics of ligand binding and activation in a glutamate receptor
@en
The hidden energetics of ligand binding and activation in a glutamate receptor
@nl
type
label
The hidden energetics of ligand binding and activation in a glutamate receptor
@ast
The hidden energetics of ligand binding and activation in a glutamate receptor
@en
The hidden energetics of ligand binding and activation in a glutamate receptor
@nl
prefLabel
The hidden energetics of ligand binding and activation in a glutamate receptor
@ast
The hidden energetics of ligand binding and activation in a glutamate receptor
@en
The hidden energetics of ligand binding and activation in a glutamate receptor
@nl
P2860
P356
P1476
The hidden energetics of ligand binding and activation in a glutamate receptor
@en
P2093
Albert Y Lau
Benoît Roux
P2860
P2888
P304
P356
10.1038/NSMB.2010
P577
2011-02-13T00:00:00Z