Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core
about
Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptorsFunctional insights from glutamate receptor ion channel structuresSize matters in activation/inhibition of ligand-gated ion channelsComputational study of synthetic agonist ligands of ionotropic glutamate receptorsGluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) Forms an Irreversible Bond To the Active Site of the GluR2 AMPA Receptor †Structure of the S1S2 glutamate binding domain of GLuR3Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4Enhanced Efficacy without Further Cleft Closure: Reevaluating Twist as a Source of Agonist Efficacy in AMPA ReceptorsBinding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonistsStructural Determinants of Agonist Efficacy at the Glutamate Binding Site of N-Methyl-D-Aspartate ReceptorsL-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domainGlutamate receptor ion channels: structure, regulation, and functionAMPA receptor ligands: synthetic and pharmacological studies of polyamines and polyamine toxins.Dorsal unpaired median neurons of locusta migratoria express ivermectin- and fipronil-sensitive glutamate-gated chloride channels.Energetics of the cleft closing transition and the role of electrostatic interactions in conformational rearrangements of the glutamate receptor ligand binding domain.Energy transfer ligands of the GluR2 ligand binding coreOn the mechanisms of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor binding to glutamate and kainate.Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acidSeven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2.The relationship between agonist potency and AMPA receptor kinetics.Role of dimer interface in activation and desensitization in AMPA receptorsPharmacological characterization of the allosteric modulator desformylflustrabromine and its interaction with alpha4beta2 neuronal nicotinic acetylcholine receptor orthosteric ligands.Allosteric mechanism in AMPA receptors: a FRET-based investigation of conformational changes.The hidden energetics of ligand binding and activation in a glutamate receptorStructural dynamics of the glycine-binding domain of the N-methyl-D-aspartate receptor.Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating.Life at the top: the transition state of AChR gating.Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery.Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors.Atomistic mechanism for the activation and desensitization of an AMPA-subtype glutamate receptorSoluble mimics of a chemokine receptor: chemokine binding by receptor elements juxtaposed on a soluble scaffoldRetour aux sources: defining the structural basis of glutamate receptor activation.Concanavalin-A reports agonist-induced conformational changes in the intact GluR6 kainate receptor.Glutamate receptors at atomic resolution.NMR spectroscopy of the ligand-binding core of ionotropic glutamate receptor 2 bound to 5-substituted willardiine partial agonists.Crystallization and preliminary X-ray crystallographic analysis of the GluR0 ligand-binding core from Nostoc punctiforme.Rigid body essential X-ray crystallography: distinguishing the bend and twist of glutamate receptor ligand binding domains.Quantifying water-mediated protein-ligand interactions in a glutamate receptor: a DFT study.
P2860
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P2860
Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
name
Structural basis for AMPA rece ...... the GluR2 ligand-binding core
@ast
Structural basis for AMPA rece ...... the GluR2 ligand-binding core
@en
Structural basis for AMPA rece ...... the GluR2 ligand-binding core
@nl
type
label
Structural basis for AMPA rece ...... the GluR2 ligand-binding core
@ast
Structural basis for AMPA rece ...... the GluR2 ligand-binding core
@en
Structural basis for AMPA rece ...... the GluR2 ligand-binding core
@nl
prefLabel
Structural basis for AMPA rece ...... the GluR2 ligand-binding core
@ast
Structural basis for AMPA rece ...... the GluR2 ligand-binding core
@en
Structural basis for AMPA rece ...... the GluR2 ligand-binding core
@nl
P2093
P1476
Structural basis for AMPA rece ...... the GluR2 ligand-binding core
@en
P2093
I K Larsen
J Egebjerg
J S Kastrup
T Liljefors
P304
P356
10.1016/S0022-2836(02)00650-2
P407
P577
2002-09-06T00:00:00Z